Evidence map›Paper›PMID 29305857›Full record

ArticleBiochemical pharmacology2018

A binding kinetics study of human adenosine A

Lizi Xia, Athina Kyrizaki, Dilip K Tosh, Tirsa T van Duijl, Jacomina Cornelia Roorda, Kenneth A Jacobson, Adriaan P IJzerman, Laura H Heitman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. AEuropean journal of medicinal chemistry · 2022
    Article
  6. Article
  7. Review
  8. Binding kinetics of ligands acting at GPCRs.Molecular and cellular endocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lizi XiaDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Athina KyrizakiDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Tirsa T van DuijlDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Jacomina Cornelia RoordaDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Adriaan P IJzermanDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands.
Laura H HeitmanDivision of Medicinal Chemistry, LACDR, Leiden University, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.
Leiden University · NLNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · US

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS ZIA DK031117
6 · The paper itself

Abstract

The human adenosine A

Indexed as

Adenosine A3 Receptor AgonistsAnimalsCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugHumansKineticsProtein BindingAdenosine A3 Receptor Agonists2-Cl-IB-MECA (PubChem CID: 3035850)Adenosine A(3) receptorBinding kineticsIB-MECA (PubChem CID: 123683)MRS3558 (PubChem CID: 11248240)MRS5698 (PubChem CID: 57523213)NucleosidesPSB-11 (PubChem CID: 9882625)Residence timeStructure-kinetics relationships

Identifiers

PMID29305857
PMCPMC5959751
OpenAlexW2781547348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.