Article in Biochimica et biophysica acta. Biomembranes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 3 institutions in 1 country.
Roopa KenothDept. of Chemistry School of Advanced Sciences, VIT, Vellore, Tamil Nadu 632014, India.
Xianqiong ZouThe Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA.
Dhirendra K SimanshuMemorial Sloan-Kettering Cancer Ctr, New York, NY, USA.
Helen M PikeThe Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA.
Lucy MalininaThe Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA.
Dinshaw J PatelMemorial Sloan-Kettering Cancer Ctr, New York, NY, USA.
Rhoderick E BrownThe Hormel Institute, University of Minnesota, 801 16th Ave NE, Austin, MN 55912, USA.
Ravi Kanth KamlekarDept. of Chemistry School of Advanced Sciences, VIT, Vellore, Tamil Nadu 632014, India. Electronic address: ravikanth.k@vit.ac.in.
University of Minnesota · USMemorial Sloan Kettering Cancer Center · USHormel (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
GLYCOLIPID TRANSFER--REGULATION BY MEMBRANE INTERFACESR01GM045928 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BROWN, RHODERICK E · 1992 to 2014
$4.8M
The functional role of the cPLA2alpha/C1P interaction in sepsis resolutionR01HL125353 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RHODERICK E, CHALFANT, CHARLES E. · 2014 to 2018
$4.0M
MOLECULAR BASIS OF GLYCOSPHINGOLIPID BINDING SPECIFICITYR01CA121493 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PATEL, DINSHAW J · 2006 to 2010
$1.2M
BLRD Research Career Scientist Award ApplicationIK6BX004603 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI CHALFANT, CHARLES E. · 2019 to 2025
HET-C2 is a fungal glycolipid transfer protein (GLTP) that uses an evolutionarily-modified GLTP-fold to achieve more focused transfer specificity for simple neutral glycosphingolipids than mammalian GLTPs. Only one of HET-C2's two Trp residues is topologically identical to the three Trp residues of mammalian GLTP. Here, we provide the first assessment of the functional roles of HET-C2 Trp residues in glycolipid binding and membrane interaction. Point mutants HET-C2
Indexed as
Protein Interaction Domains and MotifsAmino Acid SubstitutionCarrier ProteinsCell MembraneFungal ProteinsGlycolipidsModels, MolecularMutagenesis, Site-DirectedMutant ProteinsPodosporaProtein BindingStructure-Activity RelationshipTryptophanCarrier ProteinsFungal ProteinsGlycolipidsHET-C2 protein, Podospora anserinalipid transfer proteinMutant ProteinsTryptophanFluorescenceGLTPGLTP-foldGlycosphingolipid transferHET-C2Membrane bindingTrp point mutation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein. · full record | OpenQuestion