Evidence map›Paper›PMID 29305709›Full record

Trial reportJournal of cancer research and clinical oncology2018

Influence of physical activity on the immune system in breast cancer patients during chemotherapy.

Thorsten Schmidt, Walter Jonat, Daniela Wesch, Hans-Heinrich Oberg, Sabine Adam-Klages, Lisa Keller, Christoph Röcken, Christoph Mundhenke

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 8 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 8 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  4. Effects of exercise on immune cells with tumor-specific activity in breast cancer patients and survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  8. Resistance Training in Breast Cancer Survivors: A Systematic Review of Exercise Programs.International journal of environmental research and public health · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thorsten SchmidtComprehensive Cancer Center North, University of Kiel, Arnold-Heller Straße 3, Haus 14, 24105, Kiel, Germany. Thorsten.schmidt@uksh.de.ORCID http://orcid.org/0000-0002-7492-9424
Walter JonatOB/GYN, University of Kiel, Arnold-Heller Straße 3, Haus 24, 24105, Kiel, Germany.
Daniela WeschInstitute of Immunology, University of Kiel, Arnold-Heller Straße 3, 24105, Kiel, Germany.
Hans-Heinrich ObergInstitute of Immunology, University of Kiel, Arnold-Heller Straße 3, 24105, Kiel, Germany.
Sabine Adam-KlagesInstitute of Immunology, University of Kiel, Arnold-Heller Straße 3, 24105, Kiel, Germany.
Lisa KellerOB/GYN, University of Kiel, Arnold-Heller Straße 3, Haus 24, 24105, Kiel, Germany.
Christoph RöckenComprehensive Cancer Center North, University of Kiel, Arnold-Heller Straße 3, Haus 14, 24105, Kiel, Germany.
Christoph MundhenkeOB/GYN, University of Kiel, Arnold-Heller Straße 3, Haus 24, 24105, Kiel, Germany.
Christian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhysical activity can impact the immune system in different ways, e.g. by alteration of the humoral and cellular immune response. Physical activity at medium intensity enhances numbers of cytotoxic T cells, NK cells and macrophages in healthy people. The aim of this study was to compare the effects of endurance and resistance training on the immune system in breast cancer patients during adjuvant chemotherapy.

methodsIn a prospective, controlled and randomized intervention exploratory trial, 12-week supervised endurance or resistance training were compared with usual care twice a week. Endpoints were the absolute numbers of the immune cells such as CD3

resultsDespite different physical interventions in all groups immune cell count decreased in CD3 T cells including TCR αβ and CD4 T cells, NK cells and CD19 B cells 12 weeks after initiation of chemotherapy and start of the physical intervention program, while the reduction of γδ T cells and CD8 T cells is less prominent in the RT and UC group.

conclusionChemotherapy led to a decrease in nearly all measured immune cells. In this study, physical intervention with endurance or resistance training did not suppress cellular immunity any further. Larger multicenter trials are needed to evaluate the exact impact of sports intervention on immune cell subpopulations.

Indexed as

AdultAgedAntineoplastic Combined Chemotherapy ProtocolsB-LymphocytesBreast NeoplasmsChemotherapy, AdjuvantCombined Modality TherapyExerciseExercise TherapyFemaleHumansImmunity, CellularKiller Cells, NaturalLymphocyte CountMiddle AgedPhysical EnduranceBreast cancerChemotherapyImmune systemPhysical activity

Identifiers

PMID29305709
PMCPMC11813291
OpenAlexW2781908164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.