Evidence map›Paper›PMID 29305705›Full record

ReviewHerzschrittmachertherapie & Elektrophysiologie2018

Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance.

Constanze Schmidt, Rémi Peyronnet

Abstract readReview
PubMed Publisher
In one paragraph

Review in Herzschrittmachertherapie & Elektrophysiologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Cardiac fibroblasts : Active players in (atrial) electrophysiology?Herzschrittmachertherapie & Elektrophysiologie · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Constanze SchmidtDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany.
Rémi PeyronnetInstitute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center - University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Straße 2q, 79110, Freiburg, Germany. remi.peyronnet@universitaets-herzzentrum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ion channels are essential for electrical signaling and contractility in cardiomyocytes. Detailed knowledge about the molecular function and regulation of cardiac ion channels is crucial for understanding cardiac physiology and pathophysiology especially in the field of arrhythmias. This review aims at providing a general overview on the identity, functional characteristics, and roles of voltage-gated as well as stretch-activated potassium selective channels in the heart. In particular, we will highlight potential therapeutic targets as well as the emerging fields of future investigations.

Indexed as

AnimalsArrhythmias, CardiacAtrial RemodelingElectrocardiographyHeartHeart DiseasesHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMechanoreceptorsMechanotransduction, CellularMembrane PotentialsMyocytes, CardiacPotassium Channels, Voltage-GatedVentricular RemodelingKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPotassium Channels, Voltage-GatedArrhythmiasCardiac diseasesDrug targetMechano-transductionRemodeling

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.