ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2018
Coupling interval variability of premature ventricular contractions in patients with different underlying pathology: an insight into the arrhythmia mechanism.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Calcium-mediated force-interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study.Biomechanics and modeling in mechanobiology · 2026Article
- Distinct patterns of ventricular fibrillation onset in primary electrical diseases: insights from a retrospective multicentre registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Review
- The utility of 24-h electrocardiogram recordings for the prediction of a sufficient number of premature ventricular complexes and mapping strategy during catheter ablation.Frontiers in cardiovascular medicine · 2025Article
- Ventricular tachycardia risk prediction with an abbreviated duration mobile cardiac telemetry.Heart rhythm O2 · 2023Article
- Premature ventricular complexes and development of heart failure in a community-based population.Heart (British Cardiac Society) · 2022Article
- Electrophysiological and anatomical factors determine arrhythmic risk in acute myocardial ischaemia and its modulation by sodium current availability.Interface focus · 2021Article
- Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats.Heart rhythm O2 · 2020Article
- Catheter Ablation of Left Ventricular Summit Arrhythmia in a Patient with Critical Coronary Artery Stenosis: A Sequential Approach.The Journal of innovations in cardiac rhythm management · 2020Article
- Important tips reflected in our daily practice from the American College of Cardiology Electrophysiology Council report on premature ventricular contractions.Anatolian journal of cardiology · 2020Article
- The effect of idiopathic premature ventricular complexes on left ventricular ejection fraction.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Article
- Premature ventricular complexes: diagnostic and therapeutic considerations in clinical practice : A state-of-the-art review by the American College of Cardiology Electrophysiology Council.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Review
- Characteristics and Prevalence of Premature Ventricular Complex: A Telemedicine Study.Cardiology research · 2019Article
- Predicting value of coupling interval variability in determining the origin of ventricular premature contractions with V3 transition.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCoupling interval (CI) variability of premature ventricular contractions (PVCs) is influenced by the underlying arrhythmia mechanism. The aim of this study was to compare CI variability of PVCs in different myocardial disease entities, in order to gain insight into their arrhythmia mechanism.
methodsSixty-four patients with four underlying pathologies were included: idiopathic (n = 16), non-ischemic dilated cardiomyopathy (NIDCM) (n = 16), familial cardiomyopathy (PLN/LMNA) (n = 16), and post-MI (n = 16)-associated PVCs. The post-MI group was included as a reference, on account of its known re-entry mechanism. On Holter registrations, the first 20 CIs of the dominant PVC morphology were measured manually after which median ΔCI and mean SD of CI/√R-R (= CI of PVC corrected for underlying heart rate) were obtained. Two observers independently measured PVC CIs on pre-selected Holter registrations in order to determine inter- and intra-observer reliability.
resultsThe largest ΔCI was seen in the PLN/LMNA group (220 ms (120-295)), the lowest in the idiopathic group (120 ms (100-190)). The ΔCI in the PLN/LMNA group was significantly larger than the post-MI group (220 ms (120-295) vs 130 ms (105-155), p = 0.023). Mean SD of CI/√R-R in the PLN/LMNA group was also significantly higher than in the post-MI group (p = 0.044). Inter- and intra-observer reliability was good (ICC = 0.91 vs 0.86 and 0.96 vs 0.77, respectively).
conclusionsLow ΔCI and SD of CI/√R-R of idiopathic and NIDCM PVCs suggest that the underlying arrhythmia mechanisms might be re-entry or triggered activity. Abnormal automaticity or modulated parasystole are unlikely mechanisms. High CI variability in PLN/LMNA patients suggests that the re-entry and triggered activity are less likely mechanisms in this group.
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