Evidence map›Paper›PMID 29305671›Full record

ArticlePharmaceutical research2018

Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice.

Erika Gyengesi, Huazheng Liang, Christopher Millington, Sandra Sonego, Daniel Sirijovski, Dhanushka Gunawardena, Karthik Dhananjayan, Madhuri Venigalla, Garry Niedermayer, Gerald Münch

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Erika GyengesiDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Huazheng LiangDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia. a.liang@westernsydney.edu.au.
Christopher MillingtonDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Sandra SonegoDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Daniel SirijovskiSchool of Science and Health, Western Sydney University, Campbelltown, Australia.
Dhanushka GunawardenaDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Karthik DhananjayanDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Madhuri VenigallaDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.
Garry NiedermayerSchool of Science and Health, Western Sydney University, Campbelltown, Australia.
Gerald MünchDepartment of Pharmacology, School of Medicine, Western Sydney University, Building 30, Goldsmith Ave, Campbelltown, NSW, 2560, Australia.ORCID http://orcid.org/0000-0002-4873-7779
Western Sydney University · AUCamden and Campbelltown Hospitals · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the short- and long-term effects of Tenilsetam on chronic neuroinflammation in the GFAP-IL6 mouse.

methodsFrom 3 months of age, GFAP-IL6 mice were divided into 2 groups and fed with Tenilsetam enriched food pellets or control food pellets, respectively, for either 5 or 15 months. Total numbers of Iba-1

resultsTenilsetam decreased the total number of Iba-1

conclusionTenilsetam has anti-inflammatory effects evidenced by the decreased number of microglia in both the cerebellum and hippocampus, and decreased TNF-α levels in the GFAP-IL6 Tenilsetam fed animals.

Indexed as

Alzheimer DiseaseAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersCerebellumChronic DiseaseHippocampusHumansInflammationInterleukin-6Mice, Inbred C57BLMice, TransgenicMicrogliaPiperazinesPyruvaldehydeThiophenesAnti-Inflammatory Agents, Non-SteroidalBiomarkersInterleukin-6interleukin-6, mousePiperazinesPyruvaldehydetenilsetamThiophenesTumor Necrosis Factor-alphaalzheimer’s diseaseanti-inflammatory drugglycationmethylglyoxalmicrogliatumour necrosis factor-α

Identifiers

PMID29305671
OpenAlexW2781927070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.