Evidence map›Paper›PMID 29305631›Full record

SynthesisUrolithiasis2018

The risk of bladder cancer in patients with urinary calculi: a meta-analysis.

Zhang Yu, Wu Yue, Li Jiuzhi, Jiang Youtao, Zhang Guofei, Guo Wenbin

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Urolithiasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
    Pooled it
  2. Urolithiasis in patients with cancer.Nature reviews. Urology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. The bladder microbiome of NMIBC and MIBC patients revealed by 2bRAD-M.Frontiers in cellular and infection microbiology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhang YuDepartment of Urology, Bao An Central Hospital of Shen Zhen, Shen Zhen, Guang Dong, 518102, China.
Wu YueDepartment of Urology, Bao An Central Hospital of Shen Zhen, Shen Zhen, Guang Dong, 518102, China. wywuyue2017@163.com.
Li JiuzhiPeople's Hospital of Xin Jiang Uygur Autonomous Region, Urumqi, Xin Jiang, 830001, China.
Jiang YoutaoPeople's Hospital of Xin Jiang Uygur Autonomous Region, Urumqi, Xin Jiang, 830001, China.
Zhang GuofeiDepartment of Urology, Bao An Central Hospital of Shen Zhen, Shen Zhen, Guang Dong, 518102, China.
Guo WenbinDepartment of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China. guowenbin2017@sina.com.
People's Hospital of Xinjiang Uygur Autonomous Region · CNThird Affiliated Hospital of Southern Medical University · CNXinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this meta-analysis was to evaluate the association between a history of urinary calculi (UC) and the risk of bladder cancer (BC). A literature search was performed from inception until July 2017. Studies that reported odds ratios (OR), relative risks or hazard ratios comparing the risk of BC in patients with the history of UC vs those without the history of UC were included. Pooled odds ratios and 95% confidence interval (CI) were calculated using a random-effect or fixed-effect method. Thirteen studies were included in our analysis to assess the association between a history of UC and risk of BC. The pooled OR of BC in patients with UC was 1.87 (95% CI, 1.45-2.41). Bladder calculi [OR, 2.17 (95% CI, 1.52-3.08)] had a higher risk of BC than kidney calculi [OR, 1.39 (95% CI, 1.06-1.82)]. The subjects had a history of UC that was associated with increased BC risk both in males [OR, 2.04 (95% CI, 1.41-2.96)] and in females [OR, 2.99 (95% CI, 2.37-3.76)]. The subgroup analysis demonstrated that UC increasing risk of BC both in case-control studies [OR, 1.75 (95% CI, 1.25-2.45)] and cohort studies [OR, 2.27 (95% CI, 1.55-3.32)]. The pooled OR of BC risk in patients with UC were 1.60 (95% CI, 1.15-2.24) in America, 1.36 (95% CI, 1.14-1.64) in Europe and 3.05 (95% CI, 2.21-4.21) in Asia, respectively. Our study demonstrates a significant increased risk of BC in patients with prior UC. This finding suggests that a history of UC is associated with BC and may impact clinical management and cancer surveillance. Further studies still needed to confirm the findings.

Indexed as

Early Detection of CancerHumansOdds RatioRisk FactorsUrinary Bladder NeoplasmsUrinary CalculiBladder cancerMeta-analysisRiskUrinary calculi

Identifiers

PMID29305631
OpenAlexW2782368475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.