Evidence map›Paper›PMID 29305581›Full record

ArticleJournal of human genetics2018

An epigenome-wide methylation study of healthy individuals with or without depressive symptoms.

Mihoko Shimada, Takeshi Otowa, Taku Miyagawa, Tadashi Umekage, Yoshiya Kawamura, Miki Bundo, Kazuya Iwamoto, Tempei Ikegame, Mamoru Tochigi, Kiyoto Kasai and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. ElevatedProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
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  5. Article
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  7. Study Design and Rationale for the Mood and Methylation Study: A Platform for Multi-Omics Investigation of Depression in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2018
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Mihoko ShimadaDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Takeshi OtowaGraduate School of Clinical Psychology, Professional Degree Program in Clinical Psychology, Teikyo Heisei University, Tokyo, Japan. totowa-psy@umin.org.
Taku MiyagawaDepartment of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Tadashi UmekageDivision for Environment, Health and Safety, The University of Tokyo, Tokyo, Japan.
Yoshiya KawamuraDepartment of Psychiatry, Shonan Kamakura General Hospital, Kanagawa, Japan.
Miki BundoDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kazuya IwamotoDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-1780-692X
Tempei IkegameDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Mamoru TochigiDepartment of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hisanobu KaiyaPanic Disorder Research Center, Warakukai Med. Corp., Tokyo, Japan.
Hisashi TaniiDepartment of Psychiatry, Institute of Medical Life Science, Graduate School of Medicine, Mie University, Mie, Japan.
Yuji OkazakiDepartment of Psychiatry, Koseikai Michinoo Hospital, Nagasaki, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tsukasa SasakiDepartment of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPKumamoto University · JPTokyo Metropolitan Institute of Medical Science · JPJapan Graduate School of Education University · JPMie University · JPSan-ikukai Hospital · JPShonan Kamakura General Hospital · JPTeikyo Heisei University · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depressive disorder is a common psychiatric disorder that is thought to be triggered by both genetic and environmental factors. Depressive symptoms are an important public health problem and contribute to vulnerability to major depression. Although a substantial number of genetic and epigenetic studies have been performed to date, the detailed etiology of depression remains unclear and there are no validated biomarkers. DNA methylation is one of the major epigenetic modifications that play diverse roles in the etiology of complex diseases. In this study, we performed an epigenome-wide association study (EWAS) of DNA methylation on subjects with (N = 20) or without (N = 27) depressive symptoms in order to examine whether different levels of DNA methylation were associated with depressive tendencies. Employing methylation-array technology, a total of 363,887 methylation sites across the genomes were investigated and several candidate CpG sites associated with depressive symptoms were identified, especially annotated to genes linked to a G-protein coupled receptor protein signaling pathway. These data provide a strong impetus for validation studies using a larger cohort and support the possibility that G-protein coupled receptor protein signaling pathways are involved in the pathogenesis of depression.

Indexed as

DNA MethylationEpigenesis, GeneticEpigenomicsGenetic Association StudiesGenetic Predisposition to DiseaseComputational BiologyCpG IslandsDepressionFemaleGene Expression ProfilingGene OntologyGene Regulatory NetworksGenome-Wide Association StudyHealthy VolunteersHigh-Throughput Nucleotide SequencingHumans

Identifiers

PMID29305581
OpenAlexW2781724017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.