ArticleHeart (British Cardiac Society)2018
Arterial stiffness association with chronic inflammatory disorders in the UK Biobank study.
Article in Heart (British Cardiac Society), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Arterial stiffness in patients with moderate to severe psoriasis on long term treatment with infliximab.BMC cardiovascular disorders · 2026Article
- Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults.Journal of atherosclerosis and thrombosis · 2025Article
- Arterial Stiffness as a New Predictor of Clinical Outcome in Patients with Polycythemia Vera.Journal of clinical medicine · 2024Article
- Added value of arterial stiffness index for the 10-year atherosclerotic cardiovascular disease risk determination in a middle-aged population-based study.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Association between tobacco smoking and alcohol consumption with arterial stiffness.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort.Frontiers in epidemiology · 2023Article
- Arterial stiffness and biological parameters: A decision tree machine learning application in hypertensive participants.PloS one · 2023Article
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-COVID Syndrome: A Common Neuroimmune Ground?Diagnostics (Basel, Switzerland) · 2022Article
- Arterial stiffness nomogram identification by cluster analysis: A new approach of vascular phenotype modeling.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Association between serum uric acid and arterial stiffness in a large-aged 40-70 years old population.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Oxidative Stress Induced by High Salt Diet-Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction inAntioxidants (Basel, Switzerland) · 2022Review
- Arterial Stiffness Determinants for Primary Cardiovascular Prevention among Healthy Participants.Journal of clinical medicine · 2022Article
- Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm.Journal of clinical medicine · 2022Article
- Association Between Lipids and Arterial Stiffness for Primary Cardiovascular Prevention in a General Middle-Aged European Population.Frontiers in cardiovascular medicine · 2022Article
- Is psychosis a syndemic manifestation of historical and contemporary adversity? Findings from UK Biobank.The British journal of psychiatry : the journal of mental science · 2021Article
- Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer's Disease.Frontiers in molecular biosciences · 2021Review
- Review
- Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study: A Mediation Analysis.JAMA psychiatry · 2020Article
- Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening.Redox biology · 2019Article
- Association between increased arterial stiffness and clinical outcomes in patients with early sepsis: a prospective observational cohort study.Intensive care medicine experimental · 2019Article
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Funding
Abstract
objectiveThe present study tested the hypothesis that arterial stiffness will be elevated across overall and specific inflammatory disorders compared with an inflammation-free comparison group.
methodsAdults (n=171 125) aged 40-70 years from the UK Biobank who were cardiovascular disease (CVD) free and who had their arterial stiffness assessed at the time of study recruitment between 2006 and 2010 were included. The main exposure was represented by a global measure of chronic inflammatory disorders. Two inflammatory biomarker measures (eg, leucocytes count, granulocytes count) were included as markers of inflammation severity. The arterial stiffness index assessed by a non-invasive technique represented the study primary outcome measure.
resultsA total of 5976 (3%) participants diagnosed with inflammatory disorders and 165 149 participants without an inflammatory disorder had data on arterial stiffness. Adjusted linear regression analyses revealed a 14% increment in mean arterial stiffness for chronic inflammatory disorders (beta coefficient (β) 1.14, 95% CI 1.05 to 1.24, P=0.002) compared with no chronic inflammatory disorder. Arterial stiffness tended to increase (P value=0.031) with tertiles of leucocytes and granulocytes count. For instance, mean arterial stiffness values increased from 1.11 (95% CI 0.96 to 1.29) in the first tertile to 1.17 (95% CI 1.02 to 1.34) in the second tertile, and 1.21 (95% CI 1.05 to 1.39) in the third tertile of leucocytes count. There was evidence for similar associations with some of the most common individual inflammatory disorders, including psoriasis and rheumatoid arthritis.
conclusionArterial stiffness was associated with multiple chronic inflammatory disorders. An increasing trend in mean arterial stiffness was also documented with increasing tertiles of different inflammatory biomarkers. Future studies are needed to investigate the discriminant value of arterial stiffness to predict major CVD events within various inflammatory disorders.
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