ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
An Insula-Central Amygdala Circuit for Guiding Tastant-Reinforced Choice Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.Addiction biology · 2021Pooled it
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- Neural coding in gustatory cortex reflects consumption decisions: evidence from conditioned taste aversion.Frontiers in systems neuroscience · 2026Article
- Contribution of Rat Insular Cortex to Stimulus-Guided Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Retrieval of an Ethanol-Conditioned Taste Aversion Promotes GABAergic Plasticity in the Anterior Insular Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Integration of Glucagon-Like Peptide 1 Receptor Actions Through the Central Amygdala.Endocrinology · 2025Review
- Licking microstructure behavior classifies a spectrum of emotional states in mice.Frontiers in systems neuroscience · 2025Article
- The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.Neuroscience bulletin · 2024Review
- A population of Insula neurons encodes for social preference only after acute social isolation in mice.Nature communications · 2024Article
- Generation and Characterization of a NovelThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Recruitment of hippocampal and thalamic pathways to the central amygdala in the control of feeding behavior under novelty.Brain structure & function · 2024Article
- Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala.iScience · 2024Article
- Insula→Amygdala and Insula→Thalamus Pathways Are Involved in Comorbid Chronic Pain and Depression-Like Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- Recruitment of Hippocampal and Thalamic Pathways to the Central Amygdala in the Control of Feeding Behavior Under Novelty.Research square · 2023Article
- Linking emotional valence and anxiety in a mouse insula-amygdala circuit.Nature communications · 2023Article
- Insula Dynorphin and Kappa Opioid Receptor Systems Regulate Alcohol Drinking in a Sex-Specific Manner in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
For animals to survive, they must reliably predict during foraging which substances are suitable for consumption. Despite extensive study, the neural circuit mechanisms underlying such adaptive behavior remain poorly understood. Here, using a tastant (sucrose/quinine)-reinforced "go/no-go" task in male and female mice, we examined the anatomical and functional connectivity of the circuit linking the insular cortex (IC) to the central amygdala (CeA) and the role of this circuit in the establishment of appropriate behavioral responses. Using anatomic tracing approaches combined with optogenetics-assisted circuit mapping, we found that the gustatory region of the IC sends direct excitatory projections to the lateral division of the CeA (CeL), making monosynaptic excitatory connections with distinct populations of CeL neurons. Specific inhibition of neurotransmitter release from the CeL-projecting IC neurons prevented mice from acquiring the "no-go" response, and impaired the "go" responses in the go/no-go task. Furthermore, selective activation of the IC-CeL pathway with optogenetics drove unconditioned lick suppression in thirsty animals, induced aversive responses, and was sufficient to instruct conditioned action suppression in response to a cue predicting the optogenetic activation. These results indicate that activities in the IC-CeL circuit are critical for establishing taste-reinforced behavioral responses, including avoidance responses to an aversive tastant, and are sufficient to drive learning of anticipatory avoidance. Our findings suggest that the IC-CeL circuit plays an important role in guiding appropriate choices during foraging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.