ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Diversity and Feature Selectivity of Primate Retinal Ganglion Cells.Annual review of vision science · 2026Review
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
- Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- An image-computable spatio-chromatic receptive field model of the midget retinal ganglion cell mosaic across the retina.Journal of computational neuroscience · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Amacrine cell inputs to OFF midget ganglion cells in macaque retina.The Journal of physiology · 2025Article
- A circuit motif for color in the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Temporal Sensitivity for Achromatic and Chromatic Flicker across the Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Noncardinal Color Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Temporal sensitivity for achromatic and chromatic flicker across the visual cortex.bioRxiv : the preprint server for biology · 2024Article
- Applying Resampling and Visualization Methods in Factor Analysis to Model Human Spatial Vision.Investigative ophthalmology & visual science · 2024Article
- Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.Visual neuroscience · 2023Article
- Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism.Investigative ophthalmology & visual science · 2023Article
- Gaining the system: limits to compensating color deficiencies through post-receptoral gain changes.Journal of the Optical Society of America. A, Optics, image science, and vision · 2023Article
- Joint representations of color and form in mouse visual cortex described by random pooling from rods and cones.Journal of neurophysiology · 2023Article
- Eye drift during fixation predicts visual acuity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In primate retina, "red-green" color coding is initiated when signals originating in long (L) and middle (M) wavelength-sensitive cone photoreceptors interact antagonistically. The center-surround receptive field of "midget" ganglion cells provides the neural substrate for L versus M cone-opponent interaction, but the underlying circuitry remains unsettled, centering around the longstanding question of whether specialized cone wiring is present. To address this question, we measured the strength, sign, and spatial tuning of L- and M-cone input to midget receptive fields in the peripheral retina of macaque primates of either sex. Consistent with previous work, cone opponency arose when one of the cone types showed a stronger connection to the receptive field center than to the surround. We implemented a difference-of-Gaussians spatial receptive field model, incorporating known biology of the midget circuit, to test whether physiological responses we observed in real cells could be captured entirely by anatomical nonselectivity. When this model sampled nonselectively from a realistic cone mosaic, it accurately reproduced key features of a cone-opponent receptive field structure, and predicted both the variability and strength of cone opponency across the retina. The model introduced here is consistent with abundant anatomical evidence for nonselective wiring, explains both local and global properties of the midget population, and supports a role in their multiplexing of spatial and color information. It provides a neural basis for human chromatic sensitivity across the visual field, as well as the maintenance of normal color vision despite significant variability in the relative number of L and M cones across individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.