ArticleBone & joint research2018
A systematic review of current osteoporotic metaphyseal fracture animal models.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Mesenchymal Stem/Stromal Cells-Derived Exosomal Micro-RNA Delivery Enhances Bone Repair in Osteoporotic Conditions.Tissue engineering. Part A · 2026Article
- Comparative Biomechanical Analysis of Kirschner Wire Fixation in Dorsally Displaced Distal Radius Fractures.Life (Basel, Switzerland) · 2024Article
- An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects.Bioactive materials · 2024Article
- Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats.Stem cell research & therapy · 2024Article
- Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur.Bioengineering (Basel, Switzerland) · 2023Article
- Article
- Modulating macrophage polarization for the enhancement of fracture healing, a systematic review.Journal of orthopaedic translation · 2022Review
- Osteocyte-specific dentin matrix protein 1 : the role of mineralization regulation in low-magnitude high-frequency vibration enhanced osteoporotic fracture healing.Bone & joint research · 2022Article
- A modified method for constructing experimental rat periodontitis model.Frontiers in bioengineering and biotechnology · 2022Article
- Cortical bone thickness of the distal radius predicts the local bone mineral density.Bone & joint research · 2021Article
- Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway.International journal of molecular sciences · 2021Article
- Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.Life (Basel, Switzerland) · 2021Article
- The role of gut microbiota in bone homeostasis.Bone & joint research · 2021Article
- Fibrinolysis as a target to enhance osteoporotic fracture healing by vibration therapy in a metaphyseal fracture model.Bone & joint research · 2021Article
- Article
- The effectiveness of exercises on fall and fracture prevention amongst community elderlies: A systematic review and meta-analysis.Journal of orthopaedic translation · 2020Review
- Inflammatory response in postmenopausal osteoporotic fracture healing.Bone & joint research · 2020Article
- How much do we know about the role of osteocytes in different phases of fracture healing? A systematic review.Journal of orthopaedic translation · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe treatment of osteoporotic fractures is a major challenge, and the enhancement of healing is critical as a major goal in modern fracture management. Most osteoporotic fractures occur at the metaphyseal bone region but few models exist and the healing is still poorly understood. A systematic review was conducted to identify and analyse the appropriateness of current osteoporotic metaphyseal fracture animal models. MATERIALS AND
methodsA literature search was performed on the Pubmed, Embase, and Web of Science databases, and relevant articles were selected. A total of 19 studies were included. Information on the animal, induction of osteoporosis, fracture technique, site and fixation, healing results, and utility of the model were extracted.
resultsFracture techniques included drill hole defects (3 of 19), bone defects (3 of 19), partial osteotomy (1 of 19), and complete osteotomies (12 of 19). Drill hole models and incomplete osteotomy models are easy to perform and allow the study of therapeutic agents but do not represent the usual clinical setting. Additionally, biomaterials can be filled into drill hole defects for analysis. Complete osteotomy models are most commonly used and are best suited for the investigation of therapeutic drugs or noninvasive interventions. The metaphyseal defect models allow the study of biomaterials, which are associated with complex and comminuted osteoporotic fractures.
conclusionFor a clinically relevant model, we propose that an animal model should satisfy the following criteria to study osteoporotic fracture healing: 1) induction of osteoporosis, 2) complete osteotomy or defect at the metaphysis unilaterally, and 3) internal fixation.
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