Evidence map›Paper›PMID 29305403›Full record

ArticleDiabetes care2018

Six-Year Diabetes Incidence After Genetic Risk Testing and Counseling: A Randomized Clinical Trial.

Jason L Vassy, Wei He, Jose C Florez, James B Meigs, Richard W Grant

Registry-linked trialAbstract readLetter
In one paragraph

Article in Diabetes care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason L VassyVA Boston Healthcare System, Boston, MA jvassy@partners.org.ORCID http://orcid.org/0000-0001-6113-5564
Wei HeDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Jose C FlorezDiabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
James B MeigsDivision of General Internal Medicine, Massachusetts General Hospital, Boston, MA.
Richard W GrantDivision of Research, Kaiser Permanente, Oakland, CA.ORCID http://orcid.org/0000-0002-6164-8025

Funding

Rare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6M
Epidemiology of Precursors to Type 2 DiabetesK24DK080140 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2007 to 2016
$1.9M
Mentored Research to Improve Care for Complex Patients with DiabetesK24DK109114 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GRANT, RICHARD W · 2016 to 2020
$914k
Using Genetic Risk Information to Enhance Diabetes PreventionR21DK084527 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GRANT, RICHARD W · 2009 to 2010
$885k
Mentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 DiabetesK24DK110550 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2016 to 2020
$812k
Clinical safety and efficacy of pharmacogenetics in Veteran careIK2CX001262 · VA · VA BOSTON HEALTH CARE SYSTEM · PI VASSY, JASON L · 2016 to 2021
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CSRD VA IK2 CX001262NIDDK NIH HHS K24 DK080140NIDDK NIH HHS K24 DK109114NIDDK NIH HHS K24 DK110550NIDDK NIH HHS R21 DK084527NIDDK NIH HHS U01 DK078616
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID29305403
PMCPMC5829962

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.