Evidence map›Paper›PMID 29305304›Full record

Trial reportSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2018

Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4.

María Belén Acevedo, J Christopher Eagon, Bruce D Bartholow, Samuel Klein, Kathleen K Bucholz, Marta Yanina Pepino

Registry-linked trialOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02766322 (Pharmacokinetics and Subjective Responses to Alcohol After Bariatric Surgery), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02766322 terminatednot on this map

Pharmacokinetics and Subjective Responses to Alcohol After Bariatric Surgery

TypeobservationalSponsorUniversity of Illinois at Urbana-ChampaignRan2016 to 2022Enrolled54ConditionsObesityArmsOral Alcohol challenge test Alcohol visit first, Oral Alcohol challenge test Placebo visit first, Intravenous Alcohol Challenge Test (Clamp), Intravenous Alcohol Self-administration Test
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. AGA Clinical Practice Update on Bariatric Surgery in Cirrhosis: Expert Review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

María Belén AcevedoDepartment of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois.
J Christopher EagonDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Bruce D BartholowDepartment of Psychological Sciences, University of Missouri, Columbia, Missouri.
Samuel KleinCenter for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, University School of Medicine, St. Louis, Missouri.
Kathleen K BucholzDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.
Marta Yanina PepinoDepartment of Food Science and Human Nutrition, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois; Division of Nutritional Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana-Champaign, Illinois. Electronic address: ypepino@illinois.edu.
University of Illinois Urbana-Champaign · USWashington University in St. Louis · USAtkins (United States) · USUniversity of Missouri · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI SHER, KENNETH JAMES · 1999 to 2008
$12.6M
Resource CoreP60AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2009 to 2013
$8.8M
PHARMACOKINETICS AND SUBJECTIVE RESPONSES TO ALCOHOL AFTER BARIATRIC SURGERYR01AA024103 · NIAAA · WASHINGTON UNIVERSITY · PI MARTA YANINA PEPINO DE GRUEV · 2016 to 2026
$3.0M
PHARMACOKINETICS AND PHARMACOLOGICAL EFFECTS OF ALCOHOL AFTER BARIATRIC SURGERYR21AA020018 · NIAAA · WASHINGTON UNIVERSITY · PI PEPINO DE GRUEV, MARTA YANINA · 2012 to 2013
$404k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCRR NIH HHS UL1 RR024992NIAAA NIH HHS P50 AA011998NIAAA NIH HHS P60 AA011998NIAAA NIH HHS R01 AA024103NIAAA NIH HHS R21 AA020018NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

backgroundWhile it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC.

objectivesThe aims of this study were to evaluate (1) the effect of SG, relative to RYGB and a presurgery group, on alcohol pharmacokinetics and subjective effects, and (2) whether breathalyzers are reliable in this population.

settingSingle-center prospective nonrandomized trial.

methodsWe performed alcohol challenge tests in 11 women who had SG surgery 1.9 ± .1 years ago (body mass index = 35.1 ± 6.6 kg/m

resultsBAC increased faster, peak BAC was approximately 2-fold higher, and feelings of drunkenness were heightened in both SG and RYGB groups relative to the presurgery group (P values<.001). BAC estimated from breath samples underestimated BAC by 27% (standard deviation = 13%) and missed peak BACs postsurgery.

conclusionsSG, similar to RYGB, causes marked alterations in the response to alcohol ingestion manifested by a faster and higher peak BAC. The breathalyzer is invalid to assess effects of gastric surgeries on pharmacokinetics of ingested alcohol.

Indexed as

AdultAlcoholic IntoxicationBlood Alcohol ContentBreath TestsCentral Nervous System DepressantsEthanolFemaleGastrectomyGastric BypassHumansMiddle AgedObesity, MorbidPostoperative CarePreoperative CareProspective StudiesBlood Alcohol ContentCentral Nervous System DepressantsEthanolAlcoholBariatric surgeryBreathalyzerEthanolMetabolic surgeryPharmacokineticsSleeve gastrectomy

Identifiers

PMID29305304
PMCPMC5844810
OpenAlexW2767249010

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.