ReviewPhysiology & behavior2018
From appetite setpoint to appetition: 50years of ingestive behavior research.
Review in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Comparing body composition between the sweet-liking phenotypes: experimental data, systematic review and individual participant data meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Postprandial sodium sensing by enteric neurons in Drosophila.Nature metabolism · 2024Article
- The neural basis of sugar preference.Nature reviews. Neuroscience · 2022Review
- Review
- Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition.Peptides · 2021Review
- Edograms: recording the microstructure of meal intake in humans-a window on appetite mechanisms.International journal of obesity (2005) · 2020Review
- 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications.Physiology & behavior · 2020Review
- Cannabinoid CBNutrients · 2020Article
- Effects of Sweet-Liking on Body Composition Depend on Age and Lifestyle: A Challenge to the Simple Sweet-Liking-Obesity Hypothesis.Nutrients · 2020Article
- Evidence that novel flavors unconditionally suppress weight gain in the absence of flavor-calorie associations.Learning & behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
I review the main themes of my 50-year research career in ingestive behavior as a graduate student at the University of Chicago and a professor at the City University of New York. A seminar course with my Ph.D. mentor, S. P. Grossman, sparked my interest in the hypothalamic obesity syndrome. I developed a wire knife to dissect the neuropathways and the functional disorder responsible for the syndrome. An elevated appetite setpoint that permitted the overconsumption of palatable foods appeared central to the hypothalamic syndrome. In brain-intact rats, providing an assortment of highly palatable foods (the cafeteria diet) stimulated diet-induced obesity that mimicked elements of hypothalamic obesity. Studies of the determinants of food palatability led to the discovery of a "new" carbohydrate taste (maltodextrin taste) and the confirmation of a fatty taste. In addition to oral taste receptors, gut nutrient sensors stimulated the intake/preference for carbohydrate- and fat-rich foods via an appetition process that stimulates brain reward systems. My research career greatly benefited from many diligent and creative students, collaborators and technicians and research support from my university and the National Institutes of Health.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.