ArticleParkinsonism & related disorders2018
Poor nighttime sleep is positively associated with dyskinesia in Parkinson's disease patients.
Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Acupuncture and Sleep Quality Among Patients With Parkinson Disease: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Lack variation of low slow-wave activity over time in the frontal region in NREM sleep may be associated with dyskinesia in Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Too little or too much nocturnal movements in Parkinson's disease: A practical guide to managing the unseen.Clinical parkinsonism & related disorders · 2024Article
- How sleep quality affects activities of daily living in Parkinson's disease: the mediating role of disease severity and the moderating role of cognition.Frontiers in aging neuroscience · 2023Article
- Sleep and affective disorders in relation to Parkinson's disease risk among older women from the Women's Health Initiative.Journal of affective disorders · 2022Observational
- Personalized Assessment of Insomnia and Sleep Quality in Patients with Parkinson's Disease.Journal of personalized medicine · 2022Review
- Association of sleep disturbance with Parkinson disease: evidence from the Women's Health Initiative.Menopause (New York, N.Y.) · 2022Observational
- Acupuncture in the Treatment of Parkinson's Disease with Sleep Disorders and Dose Response.BioMed research international · 2022Article
- Worse Sleep Quality Aggravates the Motor and Non-Motor Symptoms in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person.Medical sciences (Basel, Switzerland) · 2021Review
- Investigation on sleep and mental health of patients with Parkinson's disease during the Coronavirus disease 2019 pandemic.Sleep medicine · 2020Article
- Risk thresholds of levodopa dose for dyskinesia in Chinese patients with Parkinson's disease: a pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Sleep Disorders in Rodent Models of Parkinson's Disease.Frontiers in pharmacology · 2019Review
- Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances.BMC neurology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDyskinesia is a troublesome complication of long-term dopaminergic medications in Parkinson's disease (PD) patients. Many factors are reported to be associated with dyskinesia in PD.
objectiveTo investigate the association between sleep quality and dyskinesia in patients with PD.
methodsFour hundred twenty-five patients with PD were enrolled in this study. Demographic information was collected. Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr (H-Y) stage scale were also performed. Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were applied to evaluate daytime sleepiness and overall nighttime sleep quality, respectively, in PD patients.
resultsPatients with dyskinesia tended to have a longer duration of disease, higher daily levodopa-equivalent dose (LED), H-Y stage, UPDRS II and PSQI score, and a higher percentage of levodopa treatment than those without dyskinesia. After adjusting for age, sex, age at onset of PD, disease duration, UPDRS I, UPDRS II, UPDRS III, cigarette smoking, use of different antiparkinsonian drugs, phenotype, daily LED, and restless leg syndrome (RLS), PSQI score was still associated with dyskinesia, with corresponding ORs 1.111 (95% CI, 1.004-1.229) as a continuous variable, and 2.469 (95% CI, 1.051-5.800) as a categorical variable, respectively. Further analysis of PSQI components showed that subjective sleep quality and sleep latency were associated with dyskinesia in PD patients.
conclusionsOur data showed that poor nighttime sleep is positively associated with dyskinesia in PD patients. Attention to the management of nighttime sleep quality may be beneficial to dyskinesia in patients with PD.
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