ArticleLipids in health and disease2018
High-density lipoprotein 3 cholesterol is a predictive factor for arterial stiffness: a community-based 4.8-year prospective study.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Associations between lipid abnormalities and diabetic retinopathy across a large United States national database.Eye (London, England) · 2024Article
- Association between biomarkers of inflammation and dyslipidemia in drug resistant tuberculosis in Uganda.Lipids in health and disease · 2024Article
- High density lipoprotein heterogeneity & function among Indians with coronary artery disease.The Indian journal of medical research · 2023Article
- Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population.Frontiers in public health · 2022Article
- High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important?Biomedicines · 2021Review
- Changing Perspectives on HDL: From Simple Quantity Measurements to Functional Quality Assessment.Journal of lipids · 2021Review
- Cholesterol Efflux: Does It Contribute to Aortic Stiffening?Journal of cardiovascular development and disease · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough drug trials with niacin and cholesteryl ester transfer protein inhibitors that substantially increase high-density lipoprotein-cholesterol (HDL-C) failed to reduce the risk of coronary heart disease, HDL protection of the cardiovascular system cannot be easily denied. Hence, it may be HDL subfractions that are responsible for the long-held and consistent cardioprotective association of HDL. Arterial stiffness has been increasingly recognized as a strong predictor of subclinical vascular disease, atherosclerotic disease, and cardiovascular mortality. As the association of HDL subfractions and arterial stiffness is not well characterized, we aimed to determine the relations between these two entities in a community-based longitudinal Chinese population sample.
methodsWe evaluated the associations of plasma HDL2-C and HDL3-C subfractions with arterial stiffness measured using carotid-femoral pulse wave velocity (cf-PWV) and then multivariate logistic regression in 1447 subjects (mean age 61.3 years) from a community-based population in Beijing, China.
resultsAfter a median follow-up of 4.8 years, Pearson's correlation analysis revealed that HDL3-C was negatively associated with follow-up cf-PWV (r = -0.114; P = 0.001), and there was no correlation between HDL2-C and follow-up cf-PWV (r = -0.045; P = 0.181). In the multivariate logistic regression analysis, each standard deviation (SD) increase in HDL3-C was associated with a 1.490-increased likelihood of the presence of follow-up cf-PWV [odds ratio (per SD increase in HDL3-C) 1.490; 95% confidence interval 1.021-1.470; P = 0.039), whereas there was no relation between HDL2-C and follow-up cf-PWV.
conclusionsHDL3-C subfractions were significantly and inversely associated with arterial stiffness, suggesting that HDL subfractions are likely more important than HDL-C in preventing cardiovascular disease.
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