ArticleWorld journal of surgical oncology2018
Significance of poor performance status after resection of colorectal liver metastases.
Article in World journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment.Life (Basel, Switzerland) · 2021Article
- Article
- Synchronous and metachronous liver metastases in patients with colorectal cancer-towards a clinically relevant definition.World journal of surgical oncology · 2019Article
- Current status of surgical treatment of colorectal liver metastases.World journal of clinical cases · 2018Review
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6 authors.
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Abstract
backgroundPerformance status (PS) is known as one of the strongest prognostic factors for survival in metastatic colorectal cancer patients. The aim of the present study was to analyze factors associated with poor PS assessed after resection for colorectal liver metastases and the impact on survival.
methodsAll patients undergoing curative resection for colorectal liver metastases between 2010 and 2015 in a single center were reviewed retrospectively.
resultsA total of 284 patients were included, out of whom 74 patients (26%) presented with a postoperative PS WHO > 2 precluding administration of adjuvant chemotherapy. These patients had a shorter recurrence-free survival (P = 0.002) and shorter overall survival (P < 0.001). Multivariable analysis showed that patients with PS > 2 after surgery had higher preoperative ASA score, had a higher frequency of major complications after surgery, and had more frequently synchronous liver and lung metastases. PS was found to be the strongest independent factor predicting survival (hazard ratio 0.45). When patients with postoperative PS > 2 developed recurrent disease (54 of 74), 43 (80%) received tumor specific treatment.
conclusionsPatients with postoperative PS > 2 who did not receive adjuvant chemotherapy had decreased recurrence-free and overall survival after liver resection for colorectal liver metastases. After recurrence, a large majority of these patients had had improvement in PS allowing for administration of tumor specific treatment.
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