ArticleThrombosis and haemostasis2018
Thromboelastometry and Platelet Function during Acclimatization to High Altitude.
Article in Thrombosis and haemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The Influence of Environmental Hypoxia on Hemostasis-A Systematic Review.Frontiers in cardiovascular medicine · 2022Pooled it
- Hypoxia suppresses platelet activity through GPVI down-regulation but paradoxically enhances arterial thrombosis via elevated vWF.Cardiovascular research · 2026Article
- ADP-dependent platelet activation is required for thrombus formation in mice exposed to simulated flight conditions.Blood vessels, thrombosis & hemostasis · 2026Article
- Postpartum Venous Thromboembolism: Altitudinal Gradients, Decadal Trends, and PE-Specific Risk Profiling in Highland Populations.Canadian respiratory journal · 2026Article
- Clinical changes of cardiac function from high altitude returning to plain.Scientific reports · 2025Article
- Establishing altitude-based coagulation reference ranges in Western Sichuan.Scientific reports · 2025Article
- The Impact of a High-Altitude Expedition on the Physical Performance and Nutritional Indices of Health Status of Alpinists.Journal of functional morphology and kinesiology · 2025Article
- Establishment of reference intervals for complete blood count in healthy adults at different altitudes on the Western Sichuan Plateau.Frontiers in medicine · 2025Article
- Differential expression of platelet CD147 in moderate altitude conditions: implications for coronary plaque stability assessment.Frontiers in cardiovascular medicine · 2025Article
- Are coagulation profiles in Andean highlanders with excessive erythrocytosis favouring hypercoagulability?Experimental physiology · 2024Article
- Prevalence, risk factors, and clinical characteristics of pulmonary embolism in patients with acute exacerbation of COPD in Plateau regions: a prospective cohort study.BMC pulmonary medicine · 2024Article
- Features of thromboelastogram in populations exposed to or transferring from high altitude.Heliyon · 2024Article
- Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center.Journal of clinical medicine · 2022Review
- Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude.Frontiers in physiology · 2022Article
- Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis.PloS one · 2022Article
- Practical Considerations of Dissolved Oxygen Levels for Platelet Function under Hypoxia.International journal of molecular sciences · 2021Article
- Correlations Between Intestinal Microbial Community and Hematological Profile in Native Tibetans and Han Immigrants.Frontiers in microbiology · 2021Article
- Hypoxia Modulates Platelet Purinergic Signalling Pathways.Thrombosis and haemostasis · 2020Article
- Evaluation of Oxidative Stress in Patients with Difficult-to-Heal Skin Wounds Treated with Hyperbaric Oxygen.Oxidative medicine and cellular longevity · 2020Article
- Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.International journal of molecular sciences · 2019Article
Corrections and comments
- Erratum issuedErratum to: Thromboelastometry and platelet function during acclimatisation to high altitude.2018 · MacInnis, Martin [added]; Main, Shona [corrected to Main, Shona E]; Horne, Elizabeth H [corrected to Horn, Elizabeth H]
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
Abstract
Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood from 63 healthy lowland volunteers acclimatizing to high altitude (5,200 m) using thromboelastometry and assays of platelet function to examine the effects of hypoxia on haemostasis. Using data from two separate cohorts of patients following identical ascent profiles, we detected a significant delay in clot formation, but increased clot strength by day 7 at 5,200 m. The latter finding may be accounted for by the significant rise in platelet count and fibrinogen concentration that occurred during acclimatization. Platelet function assays revealed evidence of platelet hyper-reactivity, with shortened PFA-100 closure times and increased platelet aggregation in response to adenosine diphosphate. Post-expedition results were consistent with the normalization of coagulation following descent to sea level. These robust findings indicate that hypoxia increases platelet reactivity and, with the exception of the paradoxical delay in thromboelastometry clotting time, suggest a prothrombotic phenotype at altitude. Further work to elucidate the mechanism of platelet activation in hypoxia will be important and could impact upon the management of patients with acute or chronic hypoxic respiratory diseases who are at risk of thrombotic events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.