ArticleJournal of affective disorders2018
The neurobiology of self face recognition among depressed adolescents.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Social reward processing in depressed and healthy individuals across the lifespan: A systematic review and a preliminary coordinate-based meta-analysis of fMRI studies.Behavioural brain research · 2023Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Selective encoding failure of self-face identity in subthreshold depression.Psychological research · 2026Article
- Self-Processing Circuits Among Depressed Youth After Amygdala Neurofeedback Cued to the Self-Face.Journal of neuroscience research · 2025Article
- EEG Microstates as a Functional Marker of Performance During Emotional Interference.Annals of neurosciences · 2025Article
- Novel online enfacement illusion for investigating self-perception in mental disorders: an experimental study protocol.Journal of eating disorders · 2024Article
- Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.Heliyon · 2024Article
- Article
- Hypoactive Visual Cortex, Prefrontal Cortex and Insula during Self-Face Recognition in Adults with First-Episode Major Depressive Disorder.Biomedicines · 2023Article
- The salience network is activated during self-recognition from both first-person and third-person perspectives.Human brain mapping · 2023Article
- A common self-advantage across the implicit and explicit levels for self-body recognition.Frontiers in psychology · 2023Article
- Neural Activity Associated with Symptoms Change in Depressed Adolescents following Self-Processing Neurofeedback.Brain sciences · 2022Article
- Self-Enhancement and the Medial Prefrontal Cortex: The Convergence of Clinical and Experimental Findings.Brain sciences · 2022Review
- Self-compassion and dorsolateral prefrontal cortex activity during sad self-face recognition in depressed adolescents.Psychological medicine · 2022Article
- Neural responses to facial attractiveness in the judgments of moral goodness and moral beauty.Brain structure & function · 2022Article
- Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders With and Without Gastrointestinal Symptoms.Frontiers in psychiatry · 2021Article
- Amygdala Circuitry During Neurofeedback Training and Symptoms' Change in Adolescents With Varying Depression.Frontiers in behavioral neuroscience · 2020Article
- Neurofeedback and neuroplasticity of visual self-processing in depressed and healthy adolescents: A preliminary study.Developmental cognitive neuroscience · 2019Article
- Limbic Intrinsic Connectivity in Depressed and High-Risk Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity.Frontiers in psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDepression is linked to alterations in both emotion and self-processing. The current study used functional magnetic resonance imaging (fMRI) to assess neural activation in healthy and depressed youth to a novel task that combined emotion processing with self-face recognition.
methodsAn fMRI study involving 81 adolescents (50.6% females; M
resultsDEP youth showed higher activity in the cuneus (F=26.29) and post and precentral gyri (F=20.76), across all conditions compared to HC. Sad faces elicited higher posterior cingulate cortex, precuneus (F=10.36) and inferior parietal cortex activity (F=11.0), and self faces elicited higher precuneus, fusiform (F=16.39), insula and putamen (F=16.82) activity in all youth. DEP showed higher middle temporal activity to neutral faces but lower activity to sad faces compared to HC, who showed the opposite pattern (F=12.86). DEP also showed hypoactive mid-temporal limbic activity relative to controls when identifying their self happy face vs. neutral face, yet showed hyperactivity when identifying the other happy face vs. neutral face, and HC showed the opposite pattern (F=10.94).
conclusionsThe neurophysiology of self-face recognition is altered in adolescent depression. Specifically, depression was associated with decreased activity in neural areas that support emotional and associative processing for positive self-faces and increased processing for neutral self-faces. These results suggest that depression in adolescents is associated with hypoactive emotional processing and encoding of positive self-related visual information. This abnormal neural activity at the intersection of reward and self-processing among depressed youth might have long lasting impact in self-formation and future adult self-representations, given that adolescence is a sensitive period for self-development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.