Evidence map›Paper›PMID 29304338›Full record

ArticleCell stem cell2018

The Skin(ny) on Regenerating the Largest Organ to Save a Patient's Life.

Rui Yi

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rui YiDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, USA. Electronic address: yir@colorado.edu.
University of Colorado Boulder · US

Funding

MicroRNA-mediated Regulation in Mammalian SkinR01AR059697 · NIAMS · UNIVERSITY OF COLORADO · PI YI, RUI · 2010 to 2020
$3.9M
Genetic Analysis of MicroRNA Functions in Skin Stem Cells In VivoR01AR066703 · NIAMS · UNIVERSITY OF COLORADO · PI YI, RUI · 2014 to 2024
$3.9M
Transcriptional regulation of skin stem cells and their nicheR01AR071435 · NIAMS · UNIVERSITY OF COLORADO · PI Rui Yi · 2017 to 2026
$3.8M
NIAMS NIH HHS R01 AR059697NIAMS NIH HHS R01 AR066703NIAMS NIH HHS R01 AR071435
6 · The paper itself

Abstract

Stem cells hold enormous potential to regenerate an entire organ for organ replacement therapy. Recently, in Nature, Hirsch et al. (2017) restored the expression of laminin-332 in epidermal stem cells isolated from an individual with junctional epidermolysis bullosa and grafted the entire skin back to save the patient's life.

Indexed as

Epidermolysis Bullosa, JunctionalSkinHumansLamininRegenerationStem CellsLaminin

Identifiers

PMID29304338
PMCPMC5961940
OpenAlexW2781698976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.