ArticlePloS one2018
Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Associations between olfactory dysfunction and structural MRI findings in Parkinson's disease: a systematic review.Brain imaging and behavior · 2026Pooled it
- Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies.Brain imaging and behavior · 2025Pooled it
- Altered dynamic functional connectivity and reduced higher order information interaction in Parkinson's patients with hyposmia.NPJ systems biology and applications · 2025Article
- Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities.NPJ Parkinson's disease · 2025Review
- Chemosensory Impairments and Their Impact on Nutrition in Parkinson's Disease: A Narrative Literature Review.Nutrients · 2025Review
- Olfactory Network Disruptions as Mediators of Cognitive Impairment in De Novo Parkinson's Disease.CNS neuroscience & therapeutics · 2025Article
- Does COVID-19 Trigger the Risk for the Development of Parkinson's Disease? Therapeutic Potential of Vitamin C.Molecular neurobiology · 2024Review
- Hippocampus and olfactory impairment in Parkinson disease: a comparative exploratory combined volumetric/functional MRI study.Neuroradiology · 2024Article
- Disrupted Brain Network Measures in Parkinson's Disease Patients with Severe Hyposmia and Cognitively Normal Ability.Brain sciences · 2024Article
- Functional activity, functional connectivity and complex network biomarkers of progressive hyposmia Parkinson's disease with no cognitive impairment: evidences from resting-state fMRI study.Frontiers in aging neuroscience · 2024Article
- ＜Editors' Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function.Nagoya journal of medical science · 2023Article
- Olfactory Dysfunction in Parkinson's Disease, Its Functional and Neuroanatomical Correlates.NeuroSci · 2023Review
- Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.Neural regeneration research · 2023Article
- Amplitude of low-frequency fluctuation-based regional radiomics similarity network: Biomarker for Parkinson's disease.Heliyon · 2023Article
- Olfactory dysfunction: A plausible source of COVID-19-induced neuropsychiatric symptoms.Frontiers in neuroscience · 2023Review
- Editorial: Demonstrating quality control (QC) procedures in fMRI.Frontiers in neuroscience · 2023Article
- Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms.Brain sciences · 2022Review
- Involvement of cerebellar and subcortical connector hubs in schizophrenia.NeuroImage. Clinical · 2022Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Functional Covariance Connectivity of Gray and White Matter in Olfactory-Related Brain Regions in Parkinson's Disease.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSevere hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear.
methodsWe examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs).
resultsDecreased gray matter volume (GMV) was observed in the bilateral cuneus, right associative visual area, precuneus, and some areas in anterior temporal lobes in PD-SH group compared to HCs. Both the PD-SH and PD-N/MH groups showed increased GMV in the bilateral posterior insula and its surrounding regions. A widespread significant decrease in amygdala FC beyond the decreased GMV areas and olfactory cortices were found in the PD-SH group compared with the HCs. Above all, decreased amygdala FC with the inferior parietal lobule, lingual gyrus, and fusiform gyrus was significantly correlated with both reduction of Addenbrooke's Cognitive Examination-Revised scores and severity of hyposmia in all participants. Canonical resting state networks exhibited decreased FC in the precuneus and left executive control networks but increased FC in the primary and high visual networks of patients with PD compared with HCs. Canonical network FC to other brain regions was enhanced in the executive control, salience, primary visual, and visuospatial networks of the PD-SH.
conclusionPD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contrast, relatively preserved canonical networks in combination with increased FC to brain regions outside of canonical networks may be related to compensatory mechanisms, and preservation of brain function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.