ArticleNeurorehabilitation and neural repair2018
The Relationship Between Hand Function and Overlapping Motor Representations of the Hands in the Contralesional Hemisphere in Unilateral Spastic Cerebral Palsy.
Article in Neurorehabilitation and neural repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Motor and Sensory Benefits of Mirror Therapy in Children and Adolescents with Unilateral Cerebral Palsy: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- Overlap in the cortical representation of hand and forearm muscles as assessed by navigated TMS.Neuroimage. Reports · 2023Article
- Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy.Brain sciences · 2023Review
- Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study.Journal of child neurology · 2023Article
- Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.Human brain mapping · 2022Article
- Corticomuscular coherence is reduced in relation to dorsiflexion fatigability to the same extent in adults with cerebral palsy as in neurologically intact adults.European journal of applied physiology · 2022Article
- Workshops of the Eighth International Brain-Computer Interface Meeting: BCIs: The Next Frontier.Brain computer interfaces (Abingdon, England) · 2022Article
- Transcranial magnetic stimulation as a diagnostic and therapeutic tool in cerebral palsy.Postepy psychiatrii neurologii · 2021Review
- Improvements in Upper Extremity Function Following Intensive Training Are Independent of Corticospinal Tract Organization in Children With Unilateral Spastic Cerebral Palsy: A Clinical Randomized Trial.Frontiers in neurology · 2021Article
- Effects of Transcranial Direct Current Stimulation and High-Definition Transcranial Direct Current Stimulation Enhanced Motor Learning on Robotic Transcranial Magnetic Stimulation Motor Maps in Children.Frontiers in human neuroscience · 2021Article
- Article
- Ipsilateral Corticospinal Tract Excitability Contributes to the Severity of Mirror Movements in Unilateral Cerebral Palsy: A Case Series.Clinical EEG and neuroscience · 2020Article
- Brain activation patterns underlying upper limb bilateral motor coordination in unilateral cerebral palsy: an fNIRS study.Developmental medicine and child neurology · 2020Article
- Sustained involuntary muscle activity in cerebral palsy and stroke: same symptom, diverse mechanisms.Brain communications · 2019Article
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundIn many children with unilateral spastic cerebral palsy (USCP), the corticospinal tract to the affected hand atypically originates in the hemisphere ipsilateral to the affected hand. Such ipsilateral connectivity is on average a predictor of poor hand function. However, there is high variability in hand function in these children, which might be explained by the complexity of motor representations of both hands in the contralesional hemisphere.
objectiveTo measure the link between hand function and the size and excitability of motor representations of both hands, and their overlap, in the contralesional hemisphere of children with USCP.
methodsWe used single-pulse transcranial magnetic stimulation to measure the size and excitability of motor representations of both hands, and their overlap, in the contralesional hemisphere of 50 children with USCP. We correlated these measures with manual dexterity of the affected hand, bimanual performance, and mirror movement strength.
resultsThe main and novel findings were (1) the large overlap in contralesional motor representations of the 2 hands and (2) the moderate positive associations of the size and excitability of such shared-site representations with hand function. Such functional associations were not present for overall size and excitability of representations of the affected hand.
conclusionsGreater relative overlap of the affected hand representation with the less-affected hand representation within the contralesional hemisphere was associated with better hand function. This association suggests that overlapping representations might be adaptively "yoked," such that cortical control of the child's less-affected hand supports that of the affected hand.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.