ArticleDrug delivery and translational research2019
In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds.
Article in Drug delivery and translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 123 citations in OpenAlex.
- Turning wood waste into high-value nanocellulose for sustainable agriculture environmental remediation and wound healing applications.Scientific reports · 2026Article
- Advanced Hydrogel Functionalization Strategies for Burn-Related Wound Treatment.Biomaterials research · 2026Review
- The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies.Pharmaceutics · 2025Review
- Article
- Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions.Signal transduction and targeted therapy · 2024Review
- Revolutionizing dermatology: harnessing mesenchymal stem/stromal cells and exosomes in 3D platform for skin regeneration.Archives of dermatological research · 2024Review
- Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-ResistantBiology · 2024Article
- Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential.Gels (Basel, Switzerland) · 2024Review
- Three-Dimensional Printed Cellulose for Wound Dressing Applications.3D printing and additive manufacturing · 2023Article
- Natural and Synthetic Polymeric Biomaterials for Application in Wound Management.Journal of functional biomaterials · 2023Review
- Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment.Nano-micro letters · 2023Article
- Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Dressings for Chronic Wound Management.ACS omega · 2023Review
- The contribution of immunohistochemistry to the development of hydrogels for skin repair and regeneration.European journal of histochemistry : EJH · 2023Review
- Bacterial Cellulose-Based Polymer Nanocomposites: A Review.Polymers · 2022Review
- Novel strategies for designing regenerative skin products for accelerated wound healing.3 Biotech · 2022Review
- Bilayer Hydrogels for Wound Dressing and Tissue Engineering.Polymers · 2022Review
- The Roles of the Various Cellulose Biosynthesis Operons inApplied and environmental microbiology · 2022Article
- Bacterial Cellulose and Its Applications.Polymers · 2022Review
- Functionalization and Antibacterial Applications of Cellulose-Based Composite Hydrogels.Polymers · 2022Review
- Bacterial Cellulose-A Remarkable Polymer as a Source for Biomaterials Tailoring.Materials (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The healing of wounds, including those from burns, currently exerts a burden on healthcare systems worldwide. Hydrogels are widely used as wound dressings and in the field of tissue engineering. The popularity of bacterial cellulose-based hydrogels has increased owing to their biocompatibility. Previous study demonstrated that bacterial cellulose/acrylic acid (BC/AA) hydrogel increased the healing rate of burn wound. This in vivo study using athymic mice has extended the use of BC/AA hydrogel by the addition of human epidermal keratinocytes and human dermal fibroblasts. The results showed that hydrogel loaded with cells produces the greatest acceleration on burn wound healing, followed by treatment with hydrogel alone, compared with the untreated group. The percentage wound reduction on day 13 in the mice treated with hydrogel loaded with cells (77.34 ± 6.21%) was significantly higher than that in the control-treated mice (64.79 ± 6.84%). Histological analysis, the expression of collagen type I via immunohistochemistry, and transmission electron microscopy indicated a greater deposition of collagen in the mice treated with hydrogel loaded with cells than in the mice administered other treatments. Therefore, the BC/AA hydrogel has promising application as a wound dressing and a cell carrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.