Evidence map›Paper›PMID 29302905›Full record

SynthesisInflammopharmacology2018

The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials.

Seyed Mohammad Aqaeinezhad Rudbane, Samane Rahmdel, Seyedeh Maryam Abdollahzadeh, Morteza Zare, Azam Bazrafshan, Seyed Mohammad Mazloomi

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 9 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 9 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Seyed Mohammad Aqaeinezhad RudbaneDepartment of Clinical Nutrition, Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Samane RahmdelDepartment of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Seyedeh Maryam AbdollahzadehDepartment of Clinical Nutrition, Meta-Research Innovation Office, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. abdolahsm@sums.ac.ir.
Morteza ZareNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Azam BazrafshanNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Seyed Mohammad MazloomiDepartment of Food Hygiene and Quality Control, Nutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IRKerman University of Medical Sciences · IRShiraz University · IR

Funding

Shiraz University of Medical Sciences 95-01-106-12747
6 · The paper itself

Abstract

Probiotics are considered as -immunomodulatory agents; their efficacy as an adjunct therapy option for rheumatoid arthritis (RA), however, remains controversial. The main aim of the present meta-analysis, therefore, was to compare available data from the published randomized, controlled trials (RCTs) recruiting adults with RA which compared probiotics with placebo. The English literature search was performed using Ovid version of Medline, EmBase, Web of Science, and the Central Cochrane library through October 2016 and supplemented by hand searching reference lists. Among 240 citations identified, 4 RCTs (153 participants; 89% female) were included. All data were pooled using a standardized mean difference (SMD) with a 95% CI. Compared to the placebo, probiotics did not change the inflammatory parameters (erythrocyte sedimentation rate, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-10, and IL-12) and oxidative stress indices (total antioxidant capacity and malondialdehyde) significantly. The borderline significant reduction as a result of probiotic administration was only determined in C-reactive protein [SDM - 0.32 (95% CI - 0.65 to 0.00)]. Among disease activity indices (disease activity score [DAS], tender joint count, and swollen joint count), DAS showed a significant improvement following probiotic treatment with a SMD (95% CI) of - 0.58 (- 0.97 to - 0.19). The number of trials was too small to determine if a strain-, dose-, or duration-response effect was present. Probiotics seem to be less effective in RA; however, to reach a firm conclusion, we need further evidence.

Indexed as

AdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidC-Reactive ProteinDietary SupplementsErythrocytesFemaleHumansImmunologic FactorsInflammationInterleukinsMaleMalondialdehydeMiddle AgedAntirheumatic AgentsC-Reactive ProteinImmunologic FactorsInterleukinsMalondialdehydeTumor Necrosis Factor-alphaDisease activityInflammatory factorsMeta-analysisProbioticsRandomized trialRheumatoid arthritis

Identifiers

PMID29302905
OpenAlexW2781848730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.