Observational studyClinical and experimental nephrology2018
Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis.
Observational study in Clinical and experimental nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Predicting 3-year all-cause mortality in patients undergoing hemodialysis using machine learning.Journal of nephrology · 2025Article
- History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study.Journal of bone and mineral metabolism · 2024Article
- Calcium: More Than Bone? Implications for Clinical Practice and Theory.Journal of clinical medicine research · 2021Review
- Dental caries status is associated with arteriosclerosis in patients on hemodialysis.Clinical and experimental nephrology · 2021Article
- Association of serum calcium and phosphorus with measures of left ventricular structure and function: The ARIC study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2020Article
- Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification.Experimental & molecular medicine · 2019Article
- Cardiovascular Outcomes of Calcium-Free vs Calcium-Based Phosphate Binders in Patients 65 Years or Older With End-stage Renal Disease Requiring Hemodialysis.JAMA internal medicine · 2019Observational
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Authors and funding
4 authors.
Funding
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Abstract
backgroundThe relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD).
methodsThe study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital. The primary outcomes were the 1- and 3-year all-cause and CV mortality rate, with the association between CCa level and CVD-specific mortality evaluated using the Kaplan-Meier method and Cox proportional hazard regression analysis.
resultsPatients with a high initial CCa level were at higher risk for CVD-related, but not all-cause, mortality than patients with a low initial CCa level [hazard ratio (HR) 2.81; 95% confidence interval 1.05-7.55]. The HR for CVD-related mortality was also higher for patients with an Agatston vessel calcification score > 2000 (HR 13.9; 95% CI 1.63-118.2). Overall, the 3-year CVD-free rate was 88.2% (range 76.4-94.3%). Higher CCa level was associated with a higher Agatston score and cardiac valve calcification.
conclusionHigh serum CCa levels and an Agatston score > 2000 are independent risk factors of CVD mortality due to advanced vessel calcification.
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