Evidence map›Paper›PMID 29302821›Full record

ArticlePharmaceutical research2018

Optimization of Weight Ratio for DSPE-PEG/TPGS Hybrid Micelles to Improve Drug Retention and Tumor Penetration.

Ya Jin, Zimei Wu, Caibin Li, Weisai Zhou, John P Shaw, Bruce C Baguley, Jianping Liu, Wenli Zhang

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ya JinDepartment of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Zimei WuSchool of Pharmacy, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Caibin LiDepartment of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
Weisai ZhouDepartment of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.
John P ShawSchool of Pharmacy, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Bruce C BaguleyAuckland Cancer Society Research Centre, University of Auckland, Private Bag, Auckland, 92019, New Zealand.
Jianping LiuDepartment of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China. jianpingliu1293@163.com.
Wenli ZhangDepartment of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China. zwllz@163.com.
China Pharmaceutical University · CNUniversity of Auckland · NZCancer Society of New Zealand · NZ

Funding

National Science Foundation Grant of China No. 81503005Natural Science Fundation of Jiangsu Province No. BK20140669Priority Academic Program Development of Jiangsu Higher Education Institutions and National Science and Technology Major Project No. 2017YFA0205400
6 · The paper itself

Abstract

purposeTo enhance therapeutic efficacy and prevent phlebitis caused by Asulacrine (ASL) precipitation post intravenous injection, ASL-loaded hybrid micelles with size below 40 nm were developed to improve drug retention and tumor penetration.

methodsASL-micelles were prepared using different weight ratios of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethyleneglycol-2000 (DSPE-PEG

resultsThe ASL-micelles prepared with DSPE-PEG

conclusionsThe optimized DSPE-PEG

Indexed as

MicellesAmsacrineAnimalsAntineoplastic AgentsCell Culture TechniquesCell SurvivalDelayed-Action PreparationsDrug CarriersDrug LiberationDrug StabilityHalf-LifeHumansMaleMCF-7 CellsNanoparticlesParticle Size1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)AmsacrineAntineoplastic AgentsasulacrineDelayed-Action PreparationsDrug CarriersMicellesPhosphatidylethanolaminesPolyethylene GlycolstocophersolanVitamin EasulacrineCMCdrug retentionhybrid micellesmulticellular spheroids penetration

Identifiers

PMID29302821
OpenAlexW2781783065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.