Evidence map›Paper›PMID 29302785›Full record

ArticleEuropean radiology2018

Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging.

Khoschy Schawkat, Michael Ith, Andreas Christe, Wolfgang Kühn, Yojena Chittazhathu, Lauren Bains, Val Murray Runge, Johannes T Heverhagen

Abstract read
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Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Quantitative pancreatic MRI: a pathology-based review.The British journal of radiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khoschy SchawkatDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland. k_schawkat@hotmail.com.
Michael IthDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Andreas ChristeDepartment of Radiology, Tiefenau Hospital, Bern, Switzerland.
Wolfgang KühnDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Yojena ChittazhathuDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Lauren BainsDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Val Murray RungeDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
Johannes T HeverhagenDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate prospectively the repeatability of pancreatic perfusion measurements using arterial spin labelling (ASL) and to determine the increase in perfusion due to secretin stimulation. MATERIAL AND

methodsAn (FAIR)-TrueFISP ASL sequence was applied to determine the perfusion of the pancreatic head in a 3T MRI scanner. Ten healthy volunteers (four men, six women: mean age 28.5 ± 4.6 years; age range 25-40 years) were investigated twice within 1 week. The inter-individual variability was calculated using the standard deviation. Intra-individual agreement between the first and second scan was estimated using the Pearson correlation coefficient. A paired Wilcoxon rank-sum test was used to compare perfusion at baseline (BL) and during secretin stimulation.

resultsThe mean BL perfusion of the pancreatic head was 285 ± 96 mL/100 g/min with an intra-individual correlation coefficient of 0.67 (strong) for repeated measurements. Secretin stimulation led to a significant increase (by 81%) in perfusion of the pancreatic head to 486 ±156 mL/100 g/min (p=0.002) with an intra-individual correlation of 0.29 (weak). A return to BL values was observed after 239 ± 92 s with a moderate intra-individual correlation coefficient of 0.42 for repeat measurements.

conclusionDynamic non-invasive ASL imaging of the pancreas permitted quantification of pancreatic perfusion in a clinically applicable setting. KEY POINTS: • ASL imaging of the pancreas permitted quantification of pancreatic perfusion • Secretin stimulation led to a significant increase in pancreatic perfusion • The intra-individual correlation coefficient for baseline perfusion was strong for repeated measurements.

Indexed as

AdultFemaleHumansMagnetic Resonance ImagingMalePancreasReference ValuesSecretinSecretinArterial spin labellingMRIPancreasPerfusionSecretin

Identifiers

PMID29302785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.