Evidence map›Paper›PMID 29302485›Full record

ArticleGland surgery2017

21-gene recurrence assay in patients receiving intraoperative radiotherapy: are "favorable" characteristics a surrogate for low recurrence?

Bridget A Oppong, Surupa Sen Gupta, Monique Gary, Patricia Wehner, Mihriye Mete, Danjing Zhao, Sulakshana Seevaratnam, Sonali Rudra, Shawna C Willey

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gland surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bridget A OppongDepartment of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Surupa Sen GuptaDepartment of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Monique GaryDepartment of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Patricia WehnerWashington Cancer Institute, MedStar Washington Hospital Center, Washington, DC, USA.
Mihriye MeteDepartment of Biostatics, MedStar Health Research Institute, Hyattsville, MD, USA.
Danjing ZhaoWashington Cancer Institute, MedStar Washington Hospital Center, Washington, DC, USA.
Sulakshana SeevaratnamDepartment of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Sonali RudraDepartment of Radiation Oncology, MedStar Georgetown University, Washington, DC, USA.
Shawna C WilleyDepartment of Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Georgetown University · USMedStar Georgetown University Hospital · USMedStar Washington Hospital Center · USMedStar Health · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
NCATS NIH HHS UL1 TR001409
6 · The paper itself

Abstract

backgroundIntraoperative radiotherapy (IORT) has gained momentum for early stage and favorable breast cancers (BC). The 21-gene recurrence assay guides treatment of hormone positive and node-negative BC.

methodsAnalysis of 82 invasive BC treated with breast conservation surgery (BCS) and IORT 2013-2015. Data collection included patient demographics, tumor characteristics, nodal status, recurrence test (RS) and adjuvant therapy.

resultsThe mean age was 68 years. Tumors were stage Ia (86.6%), 3.6% Ib and 9.8% IIa. Of 50 patients (61.0%) with RS testing, 72% (n=36) were low risk (RS 0-17), with 28% (n=14) at intermediate risk (RS 18-30). The 39% (n=32) of patients without RS testing, were more likely to have smaller tumors (1.3

conclusionsMost patients selected for IORT based on clinical features were indeed low risk based on RS. Given the limited long-term clinical outcome and safety data of this technique, additional investigation is needed.

Indexed as

21-gene recurrence scoreaccelerated partial breast radiationBreast cancer (BC)intraoperative radiation therapy

Identifiers

PMID29302485
PMCPMC5750322
OpenAlexW2749464742

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.