ArticleCardiovascular diagnosis and therapy2017
Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS).
Article in Cardiovascular diagnosis and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Aortic remodeling after thoracic endovascular repair combined with anti-thrombotic therapy for acute type B aortic dissection.Journal of cardiothoracic surgery · 2026Observational
- Prognostic impact of oral anticoagulation therapy and atrial fibrillation in patients with type B acute aortic dissection.Journal of arrhythmia · 2024Article
- Article
- Impact of antithrombotic therapy on clinical outcomes in patients with type B acute aortic syndrome.JTCVS open · 2023Article
- The effect of postoperative anticoagulation on acute aortic dissection: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- The effect of postoperative anticoagulation on false lumen patency after surgery for acute type A aortic dissection.Journal of cardiothoracic surgery · 2021Article
- Double Whammy: Concomitant Acute Type B Aortic Dissection and Acute Pulmonary Embolism.Vascular specialist international · 2020Article
- Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants.Open heart · 2020Article
- Anticoagulant and anti-thrombotic therapy in acute type B aortic dissection: when real-life scenarios face the shadows of the evidence-based medicine.BMC cardiovascular disorders · 2020Article
- How to prevent inadvertent emergency anticoagulation in acute type A aortic dissection: when in doubt, don't.Cardiovascular diagnosis and therapy · 2018Article
- The impact of oral anticoagulation on false lumen patency in acute type A aortic dissections.Turk gogus kalp damar cerrahisi dergisi · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly survivors of acute type A aortic dissection (AAAD) remain at risk for late death and late aortic events. However, the frequency and long-term effects of warfarin anticoagulation on long-term outcome in post-surgical AAAD survivors have not been elucidated.
methodsTwo tertiary care centers performed a retrospective observational cohort study of warfarin anticoagulation in AAAD in 243 persons with early survival of surgical repair (WATAS). Serial postoperative tomographic imaging was available in 106 persons.
resultsA total of 88 postoperative AAAD survivors (36%) were on long-term warfarin anticoagulation. The indication for anticoagulation was a mechanical aortic prosthesis in 46 (52%), atrial fibrillation in 33 (38%), stroke in 7 (8%), and pulmonary embolism in 1 (1%). The indication for anticoagulation remained unclear in 1 person (1%). Survival and aortic event free survival were 98.3±0.01 and 98.7±0.01 at 1 year, and 76.4±0.03 and 91.8±0.02 at 5 years, respectively, with no differences irrespective of warfarin anticoagulation. Multivariate Cox regression analysis established higher age (P<0.001), and operation extending into the descending aorta (P=0.030) as independent predictors of late death. Follow-up without tomographic imaging independently predicted increased long-term mortality (P<0.001) and lower rates of documented aortic events (P=0.003). Kaplan-Meyer analysis showed a relationship of aortic diameter growth ≥0.5 cm per year with late death (P=0.041) and with late aortic events (P<0.001). However, rapid aortic growth did not relate to warfarin anticoagulation.
conclusionsWarfarin anticoagulation is frequent in postsurgical AAAD and it is administered for vital indications. Warfarin anticoagulation does not relate to late mortality or to late aortic events. Rapid aortic growth predicts late mortality and late aortic events, but warfarin anticoagulation is not associated with aortic growth. Follow-up tomographic imaging is mandatory for long-term survival after surgical repair of AAAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.