ArticleJournal of gastric cancer2017
Clinical Outcomes of Endoscopic Hemostasis for Bleeding in Patients with Unresectable Advanced Gastric Cancer.
Article in Journal of gastric cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Systematic treatment in gastric cancer patients with overt bleeding: A propensity score matching analysis.World journal of clinical oncology · 2024Trial
- Hemorrhagic Complications in Gastric Cancer: Current Evidence and Multidisciplinary Management Strategies.Cancers · 2026Review
- Non-variceal upper gastrointestinal bleeding: advances and future directions in management.Clinical endoscopy · 2026Review
- Case Report: Tumor-related hemorrhage determined treatment sequencing in blastic plasmacytoid dendritic cell neoplasm coexisting with gastric cardia adenocarcinoma.Frontiers in oncology · 2026Article
- Feasibility of systemic therapy in unresectable gastric/gastroesophageal junction cancer with overt bleeding.Asia-Pacific journal of oncology nursing · 2025Article
- Hemostatic powder TC-325 as first-line treatment option for malignant gastrointestinal bleeding: a cost-utility analysis in the United Kingdom.Endoscopy · 2025Article
- Optimizing care for gastric cancer with overt bleeding: Is systemic therapy a valid option?World journal of clinical oncology · 2025Article
- Hemostatic palliative radiotherapy for gastric cancer: A literature review.Technical innovations & patient support in radiation oncology · 2024Review
- Article
- Efficacy and safety of gastroscopic hemostasis in the treatment of acute gastric hemorrhage: A meta-analysis.World journal of gastrointestinal oncology · 2023Article
- Hemostatic spray (TC-325) vs. standard endoscopic therapy for non-variceal gastrointestinal bleeding: A meta-analysis of randomized controlled trials.Endoscopy international open · 2023Review
- Palliative radiation therapy for bleeding from gastric cancer: A case series of seven patients.Clinical case reports · 2023Article
- Laparoscopic versus open surgery for locally advanced and metastatic gastric cancer complicated with bleeding and/or stenosis: short- and long-term outcomes.World journal of surgical oncology · 2022Article
- Management of non-variceal upper gastrointestinal bleeding: role of endoscopic ultrasound-guided treatments.Therapeutic advances in gastroenterology · 2022Review
- Article
- Efficacy of radiotherapy for gastric bleeding associated with advanced gastric cancer.Radiation oncology (London, England) · 2021Article
- Role of palliative radiotherapy in bleeding control in patients with unresectable advanced gastric cancer.BMC cancer · 2021Article
- Bleeding malignant gastric ulcer: successful endoscopic hemostasis with an over-the-scope clip.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2020Article
- Management of Bleeding from Unresectable Gastric Cancer.Biomedicines · 2019Review
- Effectiveness of TC-325 (Hemospray) for treatment of diffuse or refractory upper gastrointestinal bleeding - a single center experience.Endoscopy international open · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBleeding is one of the most serious complications of advanced gastric cancer (AGC) and is associated with a poor prognosis. This study aimed to evaluate the clinical outcomes of endoscopic hemostasis for bleeding in patients with unresectable AGC. MATERIALS AND
methodsThis study included 106 patients with bleeding associated with gastric cancer who had undergone endoscopic hemostasis between January 2010 and December 2013. Clinical characteristics, treatment outcomes, including rates of successful endoscopic hemostasis and rebleeding, risk factors for rebleeding, and overall survival (OS) were investigated.
resultsSuccessful initial hemostasis was achieved in 83% of patients. Rebleeding occurred in 28.3% of patients within 30 days. The median OS after initial hemostasis was lower in patients with rebleeding than in those without rebleeding (2.7 and 3.9 months, respectively, P=0.02). There were no significant differences in disease status and rebleeding rates among patients with partial response or stable disease (n=4), progressive disease (n=64), and first diagnosis of disease (n=38). Univariate and multivariate analyses (P=0.038 and 0.034, respectively) revealed that transfusion of ≥5 units of RBCs was a significant risk factor for rebleeding.
conclusionsDespite favorable success rates of endoscopic hemostasis for bleeding associated with gastric cancer, the 30-day rebleeding rate was 28.3% and the median OS was significantly lower in patients with rebleeding than in those without rebleeding. Massive transfusion (≥5 units of RBCs) was the only significant risk factor for rebleeding. Patients with bleeding associated with AGC who have undergone massive transfusion should be observed closely following endoscopic hemostasis. Further research on approaches to reduce rebleeding rate and prevent death is needed.
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