Evidence map›Paper›PMID 29302041›Full record

ArticleThe pharmacogenomics journal2018

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression.

Ismat Khatri, Christian Alexander, Klaus Brandenburg, Zhiqi Chen, Adrian Heini, Didier Heumann, Jean-Pierre Mach, Vienna Mazzoli, Ernst Rietschel, Alexey Terskikh and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Ismat KhatriInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Christian AlexanderResearch Center Borstel Leibniz-Center for Medicine and Biosciences, Borstel, Germany.
Klaus BrandenburgResearch Center Borstel Leibniz-Center for Medicine and Biosciences, Borstel, Germany.
Zhiqi ChenInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Adrian HeiniClinique La Prairie, Clarens-Montreux, Switzerland.
Didier HeumannClinique La Prairie, Clarens-Montreux, Switzerland.
Jean-Pierre MachDepartment of Biochemistry, University of Lausanne, Lausanne, Switzerland.
Vienna MazzoliInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Ernst RietschelAlsterblick 14, D-22397, Hamburg, Germany.
Alexey TerskikhSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Artur UlmerResearch Center Borstel Leibniz-Center for Medicine and Biosciences, Borstel, Germany.
Kai YuInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Ulrich ZähringerResearch Center Borstel Leibniz-Center for Medicine and Biosciences, Borstel, Germany.
Reginald GorczynskiInstitute of Medical Sciences, University of Toronto, Toronto, Canada. reg.gorczynski@utoronto.ca.ORCID http://orcid.org/0000-0002-5622-2855
University of Toronto · CAResearch Center Borstel - Leibniz Lung Center · DEClinique Valmont · CHSanford Burnham Prebys Medical Discovery Institute · USUniversity of Lausanne · CH

Funding

CIHR
6 · The paper itself

Abstract

Injections of a crude fetal sheep liver extract (FSLE) containing fetal hemoglobin, MPLA, and glutathione (GSSH) reversed cytokine changes in aged mice. To investigate the role of fetal hemoglobin we derived mice with homzygous deletions for either of the two major βchains, Hgbβ

Indexed as

Immunity, InnateAnimalsCHO CellsCricetinaeCricetulusCytokinesFetal HemoglobinFetusGlutathioneHemoglobinsHumansLiver ExtractsMiceMice, KnockoutSheepSpleenCytokinesFetal HemoglobinGlutathioneHemoglobinsLiver Extracts

Identifiers

PMID29302041
OpenAlexW2781984739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.