ArticleNature communications2018
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
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- Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.Nature communications · 2024Article
- What we need to know about the germ-free animal models.AIMS microbiology · 2024Review
- Effects of the commensal microbiota on spleen and mesenteric lymph node immune function: investigation in a germ-free piglet model.Frontiers in microbiology · 2024Article
- CD4Nature immunology · 2023Review
- Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study.Molecular biomedicine · 2022Review
- Keeping T cell memories in mind.Trends in immunology · 2022Review
- Runx3 drives a CD8Nature immunology · 2022Article
- PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu.Frontiers in immunology · 2022Article
- Clinical predictive value of naïve and memory T cells in advanced NSCLC.Frontiers in immunology · 2022Article
- A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes.Nature communications · 2021Article
- Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies.Frontiers in cellular and infection microbiology · 2021Review
- Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity.Frontiers in physiology · 2021Article
- Save your gut save your age: The role of the microbiome in stem cell ageing.Journal of cellular and molecular medicine · 2019Review
- Lymph node γδ and αβ CD8Scientific reports · 2018Article
- Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria.Frontiers in physiology · 2018Review
- Tissue-Specific Control of Tissue-Resident Memory T Cells.Critical reviews in immunology · 2018Review
- Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.