ArticleNature communications2018
A neural basis for antagonistic control of feeding and compulsive behaviors.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 71 citations in OpenAlex.
- A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.bioRxiv : the preprint server for biology · 2026Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit.Science advances · 2025Article
- Edinger-Westphal Urocortin-1 neurons regulate consumption and affect.Cell reports · 2025Article
- Exendin-4(1-32)K-Capric Acid, a Glucagon-Like Peptide-1 Receptor Agonist, Suppresses Food Intake via Arcuate Pro-Opiomelanocortin Neurons.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.Experimental & molecular medicine · 2025Review
- Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.Nature communications · 2025Article
- The paraventricular nucleus of the hypothalamus: a key node in the control of behavioural states.The Journal of physiology · 2025Review
- The midline thalamic nucleus reuniens promotes compulsive-like grooming in rodents.Translational psychiatry · 2025Article
- Smoking, Obesity, and Post-Cessation Weight Gain: Neurobiological Intersection and Treatment Recommendations.Journal of multidisciplinary healthcare · 2025Review
- Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice.BMC biology · 2024Article
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models.Neuroscience bulletin · 2024Review
- Article
- Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide.Neuroscience bulletin · 2024Review
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
- Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A thalamic nucleus reuniens-lateral septum-lateral hypothalamus circuit for comorbid anxiety-like behaviors in chronic itch.Science advances · 2024Article
- Article
- Neural substrates for regulating self-grooming behavior in rodents.Journal of Zhejiang University. Science. B · 2024Review
- A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.Nature methods · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Abnormal feeding often co-exists with compulsive behaviors, but the underlying neural basis remains unknown. Excessive self-grooming in rodents is associated with compulsivity. Here, we show that optogenetically manipulating the activity of lateral hypothalamus (LH) projections targeting the paraventricular hypothalamus (PVH) differentially promotes either feeding or repetitive self-grooming. Whereas selective activation of GABAergic LH→PVH inputs induces feeding, activation of glutamatergic inputs promotes self-grooming. Strikingly, targeted stimulation of GABAergic LH→PVH leads to rapid and reversible transitions to feeding from induced intense self-grooming, while activating glutamatergic LH→PVH or PVH neurons causes rapid and reversible transitions to self-grooming from voracious feeding induced by fasting. Further, specific inhibition of either LH→PVH GABAergic action or PVH neurons reduces self-grooming induced by stress. Thus, we have uncovered a parallel LH→PVH projection circuit for antagonistic control of feeding and self-grooming through dynamic modulation of PVH neuron activity, revealing a common neural pathway that underlies feeding and compulsive behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.