Evidence map›Paper›PMID 29302013›Full record

ArticleScience (New York, N.Y.)2018

Elevated

Veron Ramsuran, Vivek Naranbhai, Amir Horowitz, Ying Qi, Maureen P Martin, Yuko Yuki, Xiaojiang Gao, Victoria Walker-Sperling, Gregory Q Del Prete, Douglas K Schneider and 16 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 105 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 13 institutions in 5 countries.

Veron RamsuranCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0003-1590-9893
Vivek NaranbhaiCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0003-4281-8882
Amir HorowitzDepartment of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4602-1440
Ying QiCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Maureen P MartinCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Yuko YukiCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Xiaojiang GaoCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Victoria Walker-SperlingCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.ORCID 0000-0001-7847-7931
Gregory Q Del PreteAIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0001-6180-5361
Douglas K SchneiderAIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jeffrey D LifsonAIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jacques FellaySchool of Life Sciences, École Polytechnique Fédérale de Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0002-8240-939X
Steven G DeeksDepartment of Medicine University of California, San Francisco, CA 94143, USA.ORCID 0000-0001-6371-747X
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-9773-3256
James J GoedertInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.
Steven M WolinskyDivision of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Nelson L MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-5882-5548
Gregory D KirkDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Susan BuchbinderDepartment of Medicine University of California, San Francisco, CA 94143, USA.
David HaasVanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0002-5813-1594
Thumbi Ndung'uRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0003-2962-3992
Philip GoulderAfrican Health Research Institute, Durban, South Africa.ORCID 0000-0002-9842-4674
Peter ParhamDepartments of Structural Biology and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Bruce D WalkerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-6122-9245
Jonathan M CarlsonMicrosoft Research, Redmond, WA 98052, USA.ORCID 0000-0001-6618-3653
Mary CarringtonCancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. carringm@mail.nih.gov.ORCID 0000-0002-2692-2180
Leidos (United States) · USUniversity of California, San Francisco · USNational Institutes of Health · USRagon Institute of MGH, MIT and Harvard · USÉcole Polytechnique Fédérale de Lausanne · CHIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USMicrosoft (United States) · USNorthwestern University · USStanford University · USUniversity of Oxford · GBVanderbilt University · USWalter Reed Army Institute of Research · US

Funding

Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
Pharmacogenomics of HIV TherapyR01AI077505 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAAS, DAVID W · 2008 to 2025
$12.3M
Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
Howard Hughes Medical InstituteNIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI077505NIAID NIH HHS R01 AI133673NIAID NIH HHS U01 AI035039NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI069496
6 · The paper itself

Abstract

The highly polymorphic human leukocyte antigen (

Indexed as

AllelesCD4 Lymphocyte CountCohort StudiesHIVHIV InfectionsHLA AntigensHumansKiller Cells, NaturalLigandsNK Cell Lectin-Like Receptor Subfamily CProtein Sorting SignalsViremiaHLA AntigensKLRC1 protein, humanLigandsNK Cell Lectin-Like Receptor Subfamily CProtein Sorting Signals

Identifiers

PMID29302013
PMCPMC5933048
OpenAlexW2781915343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.