Evidence map›Paper›PMID 29301967›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Demography and mating system shape the genome-wide impact of purifying selection in

Benjamin Laenen, Andrew Tedder, Michael D Nowak, Per Toräng, Jörg Wunder, Stefan Wötzel, Kim A Steige, Yiannis Kourmpetis, Thomas Odong, Andreas D Drouzas and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Benjamin LaenenDepartment of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Andrew TedderDepartment of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Michael D NowakDepartment of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Per TorängDepartment of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden.
Jörg WunderMax Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.
Stefan WötzelMax Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.
Kim A SteigeDepartment of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Yiannis KourmpetisBiometris, Wageningen University & Research Centre, 6700 AC Wageningen, The Netherlands.
Thomas OdongBiometris, Wageningen University & Research Centre, 6700 AC Wageningen, The Netherlands.
Andreas D DrouzasSchool of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Marco C A M BinkBiometris, Wageningen University & Research Centre, 6700 AC Wageningen, The Netherlands.
Jon ÅgrenDepartment of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, SE-752 36 Uppsala, Sweden; jon.agren@ebc.uu.se coupland@mpipz.mpg.de tanja.slotte@su.se.
George CouplandMax Planck Institute for Plant Breeding Research, 50829 Cologne, Germany; jon.agren@ebc.uu.se coupland@mpipz.mpg.de tanja.slotte@su.se.
Tanja SlotteDepartment of Ecology, Environment and Plant Sciences, Science for Life Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden; jon.agren@ebc.uu.se coupland@mpipz.mpg.de tanja.slotte@su.se.
Stockholm University · SEUppsala University · SEWageningen University & Research · NLMax Planck Institute for Plant Breeding Research · DEScience for Life Laboratory · SEAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer

Indexed as

Selection, GeneticSelf-FertilizationArabisEuropeGeographyMutationPolymorphism, Single NucleotideWhole Genome Sequencingbottleneckdemographic historyfitness effectsgenetic loadself-fertilization

Identifiers

PMID29301967
PMCPMC5789905
OpenAlexW2953294771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.