Evidence map›Paper›PMID 29301927›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Dual-Targeted Molecular Imaging of Cancer.

Emily B Ehlerding, Lingyi Sun, Xiaoli Lan, Dexing Zeng, Weibo Cai

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Dual-receptor PET imaging of ovarian cancer using aAmerican journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Review
  11. Review
  12. Article
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  15. Article
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  17. Article
  18. Synthesis ofPharmaceutics · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily B EhlerdingDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Lingyi SunDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dexing ZengDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania zengd@upmc.edu WCai@uwhealth.org.
Weibo CaiDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin zengd@upmc.edu WCai@uwhealth.org.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Novel Platform to achieve high avidity of heterodimers for targeted cancer imagingR21EB020737 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZENG, DEXING · 2015 to 2016
$424k
Solid-Phase Platform for the Preparation of Dual-receptor Targeted PET AgentsR21EB017317 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZENG, DEXING · 2013 to 2014
$415k
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206NIBIB NIH HHS R21 EB017317NIBIB NIH HHS R21 EB020737NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

Molecular imaging is critical to personalized and precision medicine. Although singly targeted imaging probes are making an impact both clinically and preclinically, molecular imaging strategies using bispecific probes have enabled improved visualization of cancer in recent years through synergistic targeting of two ligands. In this Focus on Molecular Imaging review, we outline how peptide-, antibody-, and nanoparticle-based platforms have affected this emerging strategy, providing examples and pointing out areas in which the greatest clinical impact may be realized.

Indexed as

AnimalsHumansImmunoglobulin FragmentsMolecular ImagingNanoparticlesNeoplasmsImmunoglobulin Fragmentsbispecific antibody fragmentcancerdual-targetedmolecular imagingpositron emission tomography

Identifiers

PMID29301927
PMCPMC5868496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.