ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Prefrontal Corticostriatal Disconnection Blocks the Acquisition of Goal-Directed Action.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.Behavioral neuroscience · 2022Pooled it
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Prefrontal Neurons Projecting to the Dorsomedial Striatum and Insular Cortex Support Reward Learning.Neuroscience bulletin · 2026Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
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- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Basal forebrain and prelimbic cortex connectivity is related to behavioral response in an attention task.iScience · 2024Article
- Prior experience with behavioral control over stress facilitates social dominance.Neurobiology of stress · 2024Article
- Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.Nature communications · 2023Article
- Prefrontal cortex neurons in adult rats exposed to early life stress fail to appropriately signal the consequences of motivated actions.Physiology & behavior · 2023Article
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- Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex.iScience · 2023Article
- Distributed processing for value-based choice by prelimbic circuits targeting anterior-posterior dorsal striatal subregions in male mice.Nature communications · 2023Article
- Elevated prefrontal dopamine interferes with the stress-buffering properties of behavioral control in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Opponent Learning with Different Representations in the Cortico-Basal Ganglia Circuits.eNeuro · 2023Article
- Early life adversity impaired dorsal striatal synaptic transmission and behavioral adaptability to appropriate action selection in a sex-dependent manner.Frontiers in synaptic neuroscience · 2023Article
- Distinct cortico-striatal compartments drive competition between adaptive and automatized behavior.PloS one · 2023Article
- Divergent encoding of active avoidance behavior in corticostriatal and corticolimbic projections.Scientific reports · 2022Article
- Distinct Medial Orbitofrontal-Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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3 authors.
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Abstract
The acquisition of goal-directed action requires encoding of the association between an action and its specific consequences or outcome. At a neural level, this encoding has been hypothesized to involve a prefrontal corticostriatal circuit involving the projection from the prelimbic cortex (PL) to the posterior dorsomedial striatum (pDMS); however, no direct evidence for this claim has been reported. In a series of experiments, we performed functional disconnection of this pathway using targeted lesions of the anterior corpus callosum to disrupt contralateral corticostriatal projections with asymmetrical lesions of the PL and/or pDMS to block plasticity in this circuit in rats. We first demonstrated that unilaterally blocking the PL input to the pDMS prevented the phosphorylation of extracellular signal-related kinase/mitogen activated protein kinase (pERK/pMAPK) induced by instrumental training. Next, we used a full bilateral disconnection of the PL from the pDMS and assessed goal-directed action using an outcome-devaluation test. Importantly, we found evidence that rats maintaining an ipsilateral and/or contralateral connection between the PL and the pDMS were able to acquire goal-directed actions. In contrast, bilateral PL-pDMS disconnection abolished the acquisition of goal-directed actions. Finally, we used a temporary pharmacological disconnection to disrupt PL inputs to the pDMS by infusing the NMDA antagonist dl-2-amino-5-phosphonopentanoic acid into the pDMS during instrumental training and found that this manipulation also disrupted goal-directed learning. These results establish that, in rats, the acquisition of new goal-directed actions depends on a prefrontal-corticostriatal circuit involving a connection between the PL and the pDMS.
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