Evidence map›Paper›PMID 29301861›Full record

ArticleThe Journal of general physiology2018

Molecular determinants of pH regulation in the cardiac Na

Scott John, Brian Kim, Riccardo Olcese, Joshua I Goldhaber, Michela Ottolia

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Structural dynamics of NaCommunications biology · 2024
    Article
  8. Article
  9. The context-dependent role of the NaPflugers Archiv : European journal of physiology · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Modulation of the cardiac NaCell calcium · 2020
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Scott JohnDepartment of Medicine and Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Brian KimCedars-Sinai Heart Institute, Los Angeles, CA.ORCID 0000-0003-4206-016X
Riccardo OlceseDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.ORCID 0000-0003-4225-9814
Joshua I GoldhaberCedars-Sinai Heart Institute, Los Angeles, CA.
Michela OttoliaDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA mottolia@ucla.edu.ORCID 0000-0002-5114-8887
University of California, Los Angeles · USCedars-Sinai Medical Center · US

Funding

Molecular Biology of Cardiac Sodium-Calcium ExchangeR01HL048509 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLDHABER, JOSHUA I, PHILIPSON, KENNETH · 2002 to 2016
$4.7M
The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulationR01HL130308 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OTTOLIA, MICHELA · 2016 to 2019
$1.6M
Voltage-driven Structural Transitions in Voltage-Gated Calcium ChannelsR01GM110276 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2015 to 2018
$1.4M
NHLBI NIH HHS R01 HL048509NHLBI NIH HHS R01 HL130308NIGMS NIH HHS R01 GM110276
6 · The paper itself

Abstract

The cardiac Na

Indexed as

Allosteric SiteProtonsAllosteric RegulationAmino Acid SubstitutionAnimalsCalciumHistidineProtein BindingSodiumSodium-Calcium ExchangerXenopusCalciumHistidineProtonsSodiumSodium-Calcium Exchanger

Identifiers

PMID29301861
PMCPMC5806679
OpenAlexW2781846674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.