ArticleArteriosclerosis, thrombosis, and vascular biology2018
TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates G
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
44 citing papers in PubMed, 64 citations in OpenAlex.
- TMEM16A channel signalling microdomains in the regulation of vascular function.The Journal of physiology · 2026Review
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- Elastin Regulation of Vasoreactivity in Resistance Arteries.Hypertension (Dallas, Tex. : 1979) · 2025Article
- The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025Review
- Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity.Circulation research · 2025Article
- Cellular crosstalk in organotypic vasculature: mechanisms of diabetic cardiorenal complications and SGLT2i responses.Cardiovascular diabetology · 2025Article
- A QUARTER CENTURY OF CALCIUM-PERMEABLE ION CHANNEL, TRPV4: PERSPECTIVES ON EXPRESSION AND FUNCTION IN ENDOTHELIAL CELLS-TIME TO TRANSLATE.Transactions of the American Clinical and Climatological Association · 2025Review
- Vasomotor responses are similar between outbred UM-HET3 and inbred C57BL/6J male and female mouse mesenteric resistance arteries.Frontiers in physiology · 2025Article
- Transient receptor potential vanilloid 4 channel inhibition attenuates lung ischemia-reperfusion injury in a porcine lung transplant model.The Journal of thoracic and cardiovascular surgery · 2024Article
- The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair.International journal of molecular sciences · 2024Review
- Myoendothelial feedback in mouse mesenteric resistance arteries is similar between the sexes, dependent on nitric oxide synthase, and independent of TPRV4.American journal of physiology. Heart and circulatory physiology · 2024Article
- Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023Review
- Purinergic P2Y2 receptor-induced activation of endothelial TRPV4 channels mediates lung ischemia-reperfusion injury.Science signaling · 2023Article
- Bidirectional TRP/L Type CaBiomolecules · 2023Article
- Astrocytic TRPV4 Channels and Their Role in Brain Ischemia.International journal of molecular sciences · 2023Review
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Physiological levels of fluid shear stress modulate vascular function through TRPV4 sparklets.Acta biochimica et biophysica Sinica · 2022Article
- Novel Smooth Muscle CaCirculation · 2022Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Kwangseok HongFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville.
Eric L CopeFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville.
Leon J DeLalioFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville.
Corina MarzianoFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville.
Brant E IsaksonFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville.
Swapnil K SonkusareFrom the Robert M. Berne Cardiovascular Research Center (K.H., E.L.C., L.J.D., C.M., B.E.I., S.K.S.), Department of Molecular Physiology and Biological Physics (C.M., B.E.I., S.K.S.), and Department of Pharmacology (L.J.D., S.K.S), University of Virginia-School of Medicine, Charlottesville. sks2n@virginia.edu.
Norwegian Womens Public Health Association · NO
Funding
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6MParacrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4MMechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8MEndothelial TRPV and Potassium Channels Regulate Vascular FunctionR00HL121484 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2015 to 2017
$746kA novel TRPV4-eNOS signaling pathway in pulmonary endotheliumR56HL138496 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2017 to 2017
$403kEndothelial TRPV and Potassium Channels Regulate Vascular FunctionK99HL121484 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SONKUSARE, SWAPNIL K. · 2014 to 2014
$128kNHLBI NIH HHS K99 HL121484NHLBI NIH HHS R00 HL121484NHLBI NIH HHS R01 HL088554NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R56 HL138496NHLBI NIH HHS T32 HL007284
Abstract
objectiveSeveral physiological stimuli activate smooth muscle cell (SMC) G APPROACH AND
resultsUsing high-speed confocal microscopy to record unitary Ca
conclusionsThese results demonstrate that SMC G
Indexed as
Calcium SignalingVasoconstrictionAdrenergic alpha-1 Receptor AgonistsAnimalsBiosensing TechniquesBlood PressureCalciumCalmodulinCell CommunicationEndothelium, VascularFeedback, PhysiologicalGreen Fluorescent ProteinsInositol 1,4,5-TrisphosphateKineticsMaleMesenteric ArteriesAdrenergic alpha-1 Receptor AgonistsCalciumCalmodulinenhanced green fluorescent proteinGreen Fluorescent ProteinsInositol 1,4,5-TrisphosphateReceptors, Adrenergic, alpha-1Receptors, Thromboxane A2, Prostaglandin H2Trpv4 protein, mouseTRPV Cation ChannelsType C Phospholipasesendothelial cellsgap junctionsheterocellular communicationTRPV cation channelvasoconstriction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.