Evidence map›Paper›PMID 29301780›Full record

ArticleAJNR. American journal of neuroradiology2018

Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade.

S Vajapeyam, D Brown, P R Johnston, K I Ricci, M W Kieran, H G W Lidov, T Y Poussaint

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

S VajapeyamFrom the Departments of Radiology (S.V., D.B., P.R.J., T.Y.P.) sridhar.vajapeyam@childrens.harvard.edu.ORCID 0000-0002-1782-1919
D BrownFrom the Departments of Radiology (S.V., D.B., P.R.J., T.Y.P.).ORCID 0000-0002-7636-9168
P R JohnstonFrom the Departments of Radiology (S.V., D.B., P.R.J., T.Y.P.).ORCID 0000-0002-9642-7687
K I RicciCancer Center (K.I.R.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-7662-1220
M W KieranDivision of Pediatric Oncology (M.W.K.), Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.ORCID 0000-0003-2184-7692
H G W LidovPathology (H.G.W.L.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-1839-7603
T Y PoussaintFrom the Departments of Radiology (S.V., D.B., P.R.J., T.Y.P.).ORCID 0000-0002-0814-0791
Harvard University · USHesco (United States) · USBoston Children's Hospital · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAccurate tumor grading is essential for treatment planning of pediatric brain tumors. We hypothesized that multiparametric analyses of a combination of permeability metrics and ADC histogram metrics would differentiate high- and low-grade tumors with high accuracy. MATERIALS AND

methodsDTI and dynamic contrast-enhanced MR imaging using T1-mapping with flip angles of 2°, 5°, 10°, and 15°, followed by a 0.1-mmol/kg body weight gadolinium-based bolus was performed on all patients in addition to standard MR imaging. Permeability data were processed and transfer constant from the blood plasma into the extracellular extravascular space, rate constant from the extracellular extravascular space back into blood plasma, extravascular extracellular volume fraction, and fractional blood plasma volume were calculated from 3D tumor volumes. Apparent diffusion coefficient histogram metrics were calculated for 3 separate tumor volumes derived from T2-FLAIR sequences, T1 contrast-enhanced sequences, and permeability maps, respectively.

resultsResults from 41 patients (0.3-16.76 years of age; mean, 6.22 years) with newly diagnosed contrast-enhancing brain tumors (16 low-grade; 25 high-grade) were included in the institutional review board-approved retrospective analysis. Wilcoxon tests showed a higher transfer constant from blood plasma into extracellular extravascular space and rate constant from extracellular extravascular space back into blood plasma, and lower extracellular extravascular volume fraction (

conclusionsADC histogram metrics combined with permeability metrics differentiate low- and high-grade pediatric brain tumors with high accuracy.

Indexed as

AdolescentBrain NeoplasmsChildChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMaleNeoplasm GradingPermeabilityRetrospective StudiesROC Curve

Identifiers

PMID29301780
PMCPMC7655330
OpenAlexW2782414034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.