ReviewAJNR. American journal of neuroradiology2018
What Have We Learned from Perfusion MRI in Multiple Sclerosis?
Review in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic effectiveness of deep learning-based MRI in predicting multiple sclerosis: A meta-analysis.Neurosciences (Riyadh, Saudi Arabia) · 2024Pooled it
- Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis-A Systematic Review.Frontiers in neurology · 2022Pooled it
- A phase 2A/B randomized trial of metabolic modulators intranasal insulin and empagliflozin for MCI and early AD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Trial
- Prefrontal Neurovascular Coupling Abnormalities Associated With Cognitive Performance in Multiple Sclerosis.CNS neuroscience & therapeutics · 2026Article
- Regional IVIM-DWI Abnormalities in Normal-Appearing White Matter and Lesion Tissue in Relapsing-Remitting Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Impaired cerebrovascular reactivity is associated with disability and cognitive performance in relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Investigating the association between grey matter hypoperfusion and atrophy in multiple sclerosis using arterial spin labelling.Brain communications · 2026Article
- Investigating the Role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging in Evaluating Multiple Sclerosis Lesions.Diagnostics (Basel, Switzerland) · 2025Article
- Non-invasive Assessment of Cerebral Hemodynamics Using Resting-State Functional Magnetic Resonance Imaging in Multiple Sclerosis and Age-Related White Matter Lesions.Human brain mapping · 2024Article
- Differentiation of MS lesions through analysis of microvascular distribution.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Pathophysiology of multiple sclerosis damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in multiple sclerosis using magnetic resonance imaging.European journal of neurology · 2023Article
- Association of multiple sclerosis with chronic fatigue syndrome, restless legs syndrome, and various sleep disorders, along with the recent updates.Annals of medicine and surgery (2012) · 2023Article
- Changes in brain perfusion with training-related visuomotor improvement in MS.Frontiers in molecular neuroscience · 2023Article
- Tissue factor as a potential coagulative/vascular marker in relapsing-remitting multiple sclerosis.Frontiers in immunology · 2023Observational
- Cerebral blood flow dependency on systemic arterial circulation in progressive multiple sclerosis.European radiology · 2022Article
- The landscape of brain tumor mimics in neuro-oncology practice.Journal of neuro-oncology · 2022Article
- Dynamic contrast-enhanced (DCE) imaging: state of the art and applications in whole-body imaging.Japanese journal of radiology · 2022Review
- The comorbidity and cognition in multiple sclerosis (CCOMS) neuroimaging protocol: Study rationale, MRI acquisition, and minimal image processing pipelines.Frontiers in neuroimaging · 2022Article
- Advanced spinal cord MRI in multiple sclerosis: Current techniques and future directions.NeuroImage. Clinical · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described. Mitochondrial failure, axonal degeneration, and vascular dysfunction have been hypothesized to underlie the perfusion MR imaging findings. Clinically, perfusion MR imaging could allow earlier detection of the acute focal inflammatory changes underlying relapses and new lesions, and could constitute a marker for cognitive dysfunction in MS. Nevertheless, the clinical relevance and pathogenesis of the brain perfusion changes in MS remain to be clarified.
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Registered trials
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