ArticleGenome medicine2018
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward.
Article in Genome medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers.Molecular psychiatry · 2026Article
- MLC1 alteration in human iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage.Orphanet journal of rare diseases · 2026Article
- Time-Dependent Effects of Rapid-Acting Antidepressants in iPSC-Derived Neurons from Treatment-Resistant Depression and Healthy Volunteers.Research square · 2026Article
- Induce Pluripotent Stem Cells (iPSC) Technology in Depression.Advances in experimental medicine and biology · 2024Review
- Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia.Genome medicine · 2023Article
- Advances in currentFrontiers in bioengineering and biotechnology · 2023Review
- Annotating functional effects of non-coding variants in neuropsychiatric cell types by deep transfer learning.PLoS computational biology · 2022Article
- Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems.International journal of molecular sciences · 2021Review
- Stem cell-based models and therapies: a key approach into schizophrenia treatment.Cell and tissue banking · 2021Review
- Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes.Stem cell reports · 2021Article
- The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders.Stem cells translational medicine · 2021Review
- Modeling Brain Disorders Using Induced Pluripotent Stem Cells.Cold Spring Harbor perspectives in biology · 2020Review
- Translating insights from neuropsychiatric genetics and genomics for precision psychiatry.Genome medicine · 2020Review
- Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder.Stem cell reports · 2019Article
- Self-Organized Synchronous Calcium Transients in a Cultured Human Neural Network Derived from Cerebral Organoids.Stem cell reports · 2019Article
- Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons.Molecular psychiatry · 2019Article
- Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons.Molecular psychiatry · 2019Article
- Review
- Psychiatric Genetics, Epigenetics, and Cellular Models in Coming Years.Journal of psychiatry and brain science · 2019Article
- Translating neurogenomics: deconvoluting complex brain disorders.Genome medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.