Evidence map›Paper›PMID 29301434›Full record

ArticleDrug delivery2018

Targeted tumor dual mode CT/MR imaging using multifunctional polyethylenimine-entrapped gold nanoparticles loaded with gadolinium.

Benqing Zhou, Zuogang Xiong, Peng Wang, Chen Peng, Mingwu Shen, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Benqing Zhoua Department of Radiology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , P. R. China.
Zuogang Xionga Department of Radiology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , P. R. China.
Peng Wangb State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai , P. R. China.
Chen Penga Department of Radiology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , P. R. China.
Mingwu Shenb State Key Laboratory for Modifcation of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai , P. R. China.
Serge Mignanic Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique , Université Paris Descartes, PRES Sorbonne Paris Cité , Paris , France.
Jean-Pierre Majorale Laboratoire de Chimie de Coordination du CNRS , Toulouse , France.
Xiangyang Shia Department of Radiology , Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai , P. R. China.
Donghua University · CNShanghai Tenth People's Hospital · CNInstitut National Polytechnique de Toulouse · FRLaboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques · FRTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the construction and characterization of polyethylenimine (PEI)-entrapped gold nanoparticles (AuNPs) chelated with gadolinium (Gd) ions for targeted dual mode tumor CT/MR imaging in vivo. In this work, polyethylene glycol (PEG) monomethyl ether-modified PEI was sequentially modified with Gd chelator and folic acid (FA)-linked PEG (FA-PEG) was used as a template to synthesize AuNPs, followed by Gd(III) chelation and acetylation of the remaining PEI surface amines. The formed FA-targeted PEI-entrapped AuNPs loaded with Gd (FA-Gd-Au PENPs) were well characterized in terms of structure, composition, morphology, and size distribution. We show that the FA-Gd-Au PENPs with an Au core size of 3.0 nm are water dispersible, colloidally stable, and noncytotoxic in a given concentration range. Thanks to the coexistence of Au and Gd elements within one nanoparticulate system, the FA-Gd-Au PENPs display a better X-ray attenuation property than clinical iodinated contrast agent (e.g. Omnipaque) and reasonable r

Indexed as

AnimalsCell Line, TumorColloidsContrast MediaFemaleFolic AcidGadoliniumGoldHeLa CellsHep G2 CellsHumansMagnetic Resonance ImagingMetal NanoparticlesMiceMice, Inbred BALB CMice, Inbred C57BLColloidsContrast MediaFolic AcidGadoliniumGoldPolyethylene GlycolsPolyethyleneimineCT imaginggold nanoparticlesMR imagingPolyethyleniminetumor targeting

Identifiers

PMID29301434
PMCPMC6058675
OpenAlexW2781577751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.