Evidence map›Paper›PMID 29301410›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2018

Factors Influencing the Potency of Alzheimer Inhibitors: Computational and Docking Studies.

Faten Atlam, Mohamed Awad, Rehab Salama

Open access · bronzeAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Classification of Alzheimer's Disease Stages: An Approach Using PCA-Based Algorithm.American journal of Alzheimer's disease and other dementias · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Faten Atlam1 Theoretical applied Chemistry Unit (TACU), Chemistry Department, Tanta University, Tanta, Egypt.
Mohamed Awad1 Theoretical applied Chemistry Unit (TACU), Chemistry Department, Tanta University, Tanta, Egypt.
Rehab Salama1 Theoretical applied Chemistry Unit (TACU), Chemistry Department, Tanta University, Tanta, Egypt.
Tanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Density functional theory (B3LYP/6-31G [d]) is performed to study the effect of molecular and electronic structures of the investigated β-secretase 1 (BACE1) Alzheimer's inhibitors on their biological activities and discuss the correlation between their inhibition efficiencies and quantum chemical descriptors. IC

Indexed as

Alzheimer DiseaseAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCholinesterase InhibitorsDrug DiscoveryHumansInhibitory Concentration 50Molecular Docking SimulationAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanCholinesterase InhibitorsAlzheimer’s inhibitorsBACE1computational simulationDFT and SARmolecular docking

Identifiers

PMID29301410
PMCPMC10852456
OpenAlexW2782095587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.