Evidence map›Paper›PMID 29301290›Full record

ReviewBiomedicines2018

Non Melanoma Skin Cancer Pathogenesis Overview.

Dario Didona, Giovanni Paolino, Ugo Bottoni, Carmen Cantisani

Abstract readReview
In one paragraph

Review in Biomedicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dario DidonaKlinik für Dermatologie und Allergologie, Universitätsklinikum Marburg, Baldingerstraße, 35043 Marburg, Germany. didona.dario@gmail.com.
Giovanni PaolinoDepartment of Dermatology, Sapienza Università di Roma, Rome 00100, Italy. paolgio@libero.it.
Ugo BottoniDepartment of Dermatology, Università della Magna Grecia, Catanzaro 88100, Italy. didona.dermatology@gmail.com.ORCID 0000-0002-6119-1870
Carmen CantisaniDepartment of Dermatology, Sapienza Università di Roma, Rome 00100, Italy. carmencantisanister@gmail.com.ORCID 0000-0003-2181-951X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood. However, several studies have been conducted to better explain the mechanisms that lead to malignancy; (2) Methods: We reviewed the more recent literature about the pathogenesis of non-melanoma skin cancer focusing on basal cell carcinomas, squamous cell carcinoma and actinic keratosis; (3) Results: Several papers reported genetic and molecular alterations leading to non-melanoma skin cancer. Plenty of risk factors are involved in non-melanoma skin cancer pathogenesis, including genetic and molecular alterations, immunosuppression, and ultraviolet radiation; (4) Conclusion: Although skin carcinogenesis is still not fully understood, several papers demonstrated that genetic and molecular alterations are involved in this process. In addition, plenty of non-melanoma skin cancer risk factors are now known, allowing for an effective prevention of non-melanoma skin cancer development. Compared to other papers on the same topic, our review focused on molecular and genetic factors and analyzed in detail several factors involved in non-melanoma skin cancer.

Indexed as

actinic keratosispathogenesisprecancerous conditionsskin neoplasms

Identifiers

PMID29301290
PMCPMC5874663

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.