Evidence map›Paper›PMID 29301214›Full record

ArticleMolecules (Basel, Switzerland)2017

Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions.

Guilherme A M Jardim, Daisy J B Lima, Wagner O Valença, Daisy J B Lima, Bruno C Cavalcanti, Claudia Pessoa, Jamal Rafique, Antonio L Braga, Claus Jacob, Eufrânio N da Silva Júnior and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Nanotechnology-based biomedical devices in the cancer diagnostics and therapy.Medical oncology (Northwood, London, England) · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. First report ofRSC advances · 2023
    Article
  10. Naphth[1,2-Molecules (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Synthesis of 4-Arylselanyl-1Molecules (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guilherme A M JardimDepartment of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, Brazil. victimoffate18@gmail.com.
Daisy J B LimaDepartment of Physiology and Pharmacology, Federal University of Ceará, CEP 60180-900 Fortaleza, Brazil. daisylima@gmail.com.
Wagner O ValençaDepartment of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, Brazil. wagner.valenca1987@gmail.com.
Daisy J B LimaDepartment of Physiology and Pharmacology, Federal University of Ceará, CEP 60180-900 Fortaleza, Brazil. daisylima@gmail.com.
Bruno C CavalcantiDepartment of Physiology and Pharmacology, Federal University of Ceará, CEP 60180-900 Fortaleza, Brazil. nunim_br@yahoo.com.br.
Claudia PessoaDepartment of Physiology and Pharmacology, Federal University of Ceará, CEP 60180-900 Fortaleza, Brazil. cpessoa@ufc.br.
Jamal RafiqueDepartment of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil. jamal.chm@gmail.com.ORCID 0000-0002-2336-040X
Antonio L BragaDepartment of Chemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil. braga.antonio@ufsc.br.
Claus JacobDivision of Bioorganic Chemistry, Department of Pharmacy, University of Saarland, Campus B2 1, D-66123 Saarbruecken, Germany. c.jacob@mx.uni-saarland.de.
Eufrânio N da Silva JúniorDepartment of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, Brazil. eufranio@ufmg.br.
Eduardo H G da CruzDepartment of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, UFMG, 31270-901 Belo Horizonte, Brazil. eduardoh_cruz@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC

Indexed as

Antineoplastic AgentsCatalysisCell Line, TumorCell ProliferationCell SurvivalClick ChemistryDrug Screening Assays, AntitumorHumansOrganoselenium CompoundsQuinonesRhodiumStructure-Activity RelationshipTriazolesAntineoplastic AgentsOrganoselenium CompoundsQuinonesRhodiumTriazolescancerC-H activationclick chemistrylapacholnaphthoquinoneselenium

Identifiers

PMID29301214
PMCPMC6017932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.