ReviewNeuron2018
From Maps to Multi-dimensional Network Mechanisms of Mental Disorders.
Review in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06131268 (The Role of Negr1 In Modulating Neuroplasticity in Major Depression), which is not on this map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Network-based methods for psychometric data of eating disorders: A systematic review.PloS one · 2022Pooled it
- Hyperactivity/restlessness is associated with increased functional connectivity in adults with ADHD: a dimensional analysis of resting state fMRI.BMC psychiatry · 2019Trial
- Frontoparietal paired associative stimulation versus single-site stimulation for generalized anxiety disorder: a pilot rTMS study.Journal of psychiatry & neuroscience : JPNTrial
- Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.Nature communications · 2026Article
- AI in Mental Health: Transforming Diagnosis and Management of Depression and Anxiety.Health science reports · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mapping trait justice sensitivity in the Brain: Whole-brain resting-state functional connectivity as a predictor of other-oriented not self-oriented justice sensitivity.Cognitive, affective & behavioral neuroscience · 2025Article
- Cell-cell communication dysregulation in tuberous sclerosis complex cortical tubers and focal cortical dysplasia.Acta neuropathologica communications · 2025Article
- The Virtual Parkinsonian patient.NPJ systems biology and applications · 2025Article
- Network analysis of peer attachment and internet addiction among chinese adolescents.Scientific reports · 2025Article
- Characterization of the white matter networks in schizophrenia patients with metabolic syndrome undergoing risperidone or clozapine treatment.Frontiers in neuroscience · 2025Article
- Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation.Frontiers in neuroscience · 2025Article
- Correlation Analysis of Acute Psychotic Symptom Domain Severity and Fractional Anisotropy of Brain White Matter Tracts in Schizophrenia.Sovremennye tekhnologii v meditsine · 2025Article
- Symmetry breaking organizes the brain's resting state manifold.Scientific reports · 2024Article
- The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Expectation of pain and relief: A dynamical model of the neural basis for pain-trauma co-morbidity.Neuroscience and biobehavioral reviews · 2024Review
- Multimodal active subspace analysis for computing assessment oriented subspaces from neuroimaging data.Journal of neuroscience methods · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The development of advanced neuroimaging techniques and their deployment in large cohorts has enabled an assessment of functional and structural brain network architecture at an unprecedented level of detail. Across many temporal and spatial scales, network neuroscience has emerged as a central focus of intellectual efforts, seeking meaningful descriptions of brain networks and explanatory sets of network features that underlie circuit function in health and dysfunction in disease. However, the tools of network science commonly deployed provide insight into brain function at a fundamentally descriptive level, often failing to identify (patho-)physiological mechanisms that link system-level phenomena to the multiple hierarchies of brain function. Here we describe recently developed techniques stemming from advances in complex systems and network science that have the potential to overcome this limitation, thereby contributing mechanistic insights into neuroanatomy, functional dynamics, and pathology. Finally, we build on the Research Domain Criteria framework, highlighting the notion that mental illnesses can be conceptualized as dysfunctions of neural circuitry present across conventional diagnostic boundaries, to sketch how network-based methods can be combined with pharmacological, intermediate phenotype, genetic, and magnetic stimulation studies to probe mechanisms of psychopathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.