SynthesisSchizophrenia bulletin2018
Childhood Trauma Is Associated With Severity of Hallucinations and Delusions in Psychotic Disorders: A Systematic Review and Meta-Analysis.
Synthesis in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03991377 (A Multicenter Phase II Rater-blinded Randomized Controlled Trial), which is not on this map. Cited by 129 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Phase II Rater-blinded Randomized Controlled Trial (RCT) to Compare Effectiveness of Eye Movement Desensitization Reprocessing Therapy (EMDR) vs Treatment as Usual (TAU) in First Episode Psychosis and History of Trauma.
Who cites it
129 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Guideline
- Trauma-focused psychological interventions for psychosis: Meta-analytic evidence of differential effects on delusions and hallucinations.Psychological medicine · 2026Pooled it
- Duration of Untreated Psychosis and Outcomes in First-Episode Psychosis: Systematic Review and Meta-analysis of Early Detection and Intervention Strategies.Schizophrenia bulletin · 2024Pooled it
- Association Between Childhood Adversity and Functional Outcomes in People With Psychosis: A Meta-analysis.Schizophrenia bulletin · 2023Pooled it
- Clinical outcomes in individuals at clinical high risk of psychosis who do not transition to psychosis: a meta-analysis.Epidemiology and psychiatric sciences · 2022Pooled it
- Childhood trauma and schizotypy in non-clinical samples: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2021Pooled it
- Traumatic Events, Social Adversity and Discrimination as Risk Factors for Psychosis - An Umbrella Review.Frontiers in psychiatry · 2021Pooled it
- Pooled it
- Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- The Diagnostic Spectrum of Sexual Hallucinations.Harvard review of psychiatryPooled it
- A psychological intervention for engaging dialogically with auditory hallucinations (Talking With Voices): A single-site, randomised controlled feasibility trial.Schizophrenia research · 2022Trial
- Reading characters in voices: Ratings of personality characteristics from voices predict proneness to auditory verbal hallucinations.PloS one · 2019Trial
- Differential associations of childhood trauma subtypes with clinical symptoms, cognitive function, suicidal intent, and age at onset in Chinese patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- The correlations between psychotic symptoms and childhood maltreatment as well as sex differences in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Sequelae of child maltreatment: Umbrella synthesis of 148 meta-analyses on the mental health correlates.JCPP advances · 2026Article
- The Relationship Between Trauma Exposure and Nonclinical Psychosis: A Systematic Review and Meta-Analysis.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- Childhood trauma, specifically emotional abuse, is associated with psychiatric symptom severity in drug‑naïve first‑episode patients with schizophrenia.Scientific reports · 2026Article
- Narrative Review of Catatonia in Psychosis and Eating Disorders: Common Intersections and Treatment Considerations.Early intervention in psychiatry · 2026Review
- Psychological and behavioral mechanisms linking childhood trauma profiles to voice-related distress in schizophrenia spectrum disorders: latent class, mediation, and conditional process analyses.Psychological medicine · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Childhood trauma is a risk factor for the development of psychosis. Furthermore, a number of theories propose specific mechanisms by which childhood trauma may contribute to more severe positive and negative psychotic symptoms, some of which are supported empirically. The robustness of this empirical evidence is unclear due to mixed results and methodological limitations of individual studies. A systematic review and meta-analysis of the evidence for associations between childhood trauma and severity of hallucinations, delusions, and negative psychotic symptoms in clinical populations with a diagnosed psychotic disorder is needed. Method: A systematic search was conducted. Reference lists of relevant review articles were hand-searched, and authors contacted for data and additional unpublished studies. Study reporting bias and quality was assessed. Results: In total, 6667 studies were identified and of these 41 studies met inclusion criteria. Of these, 29 studies (4680 participants) were meta-analyzed. Among individuals with psychosis, childhood trauma was significantly correlated with severity of hallucinations (r = .199, P < .001) and delusions (r = .172, P < .001) but contrary to our hypothesis, not correlated with severity of negative symptoms (r = .049, P = .095). Severity of childhood neglect was correlated with negative symptoms (r = .142, P = .005). Conclusion: The results lend support for cognitive and biological theories that traumas in childhood may lead to hallucinations and delusions within psychotic disorders and have important implications for clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.