ArticleCerebral cortex (New York, N.Y. : 1991)2019
PV+ Cells Enhance Temporal Population Codes but not Stimulus-Related Timing in Auditory Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Developmental and early-life stress-induced effects on 5-HTNeurobiology of stress · 2026Article
- Developmental and Early-Life Stress-Induced Effects on 5-HTbioRxiv : the preprint server for biology · 2025Article
- Spatial Distribution of Inhibitory Innervations of Excitatory Pyramidal Cells by Major Interneuron Subtypes in the Auditory Cortex.Bioengineering (Basel, Switzerland) · 2023Article
- A Redundant Cortical Code for Speech Envelope.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- [Comparison of electrophysiological properties of parvalbumin neurons in the tail of the striatum and the auditory cortex of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Selective effects of isoflurane on cortico-cortical feedback afferent responses in murine non-primary neocortex.British journal of anaesthesia · 2019Article
- A Spike Train Distance Robust to Firing Rate Changes Based on the Earth Mover's Distance.Frontiers in computational neuroscience · 2019Article
- Altered stimulus representation in rat auditory cortex is not causal for loss of consciousness under general anaesthesia.British journal of anaesthesia · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Spatio-temporal cortical activity patterns relative to both peripheral input and local network activity carry information about stimulus identity and context. GABAergic interneurons are reported to regulate spiking at millisecond precision in response to sensory stimulation and during gamma oscillations; their role in regulating spike timing during induced network bursts is unclear. We investigated this issue in murine auditory thalamo-cortical (TC) brain slices, in which TC afferents induced network bursts similar to previous reports in vivo. Spike timing relative to TC afferent stimulation during bursts was poor in pyramidal cells and SOM+ interneurons. It was more precise in PV+ interneurons, consistent with their reported contribution to spiking precision in pyramidal cells. Optogenetic suppression of PV+ cells unexpectedly improved afferent-locked spike timing in pyramidal cells. In contrast, our evidence suggests that PV+ cells do regulate the spatio-temporal spike pattern of pyramidal cells during network bursts, whose organization is suited to ensemble coding of stimulus information. Simulations showed that suppressing PV+ cells reduces the capacity of pyramidal cell networks to produce discriminable spike patterns. By dissociating temporal precision with respect to a stimulus versus internal cortical activity, we identified a novel role for GABAergic cells in regulating information processing in cortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.